Role of BMP Signaling for the Formation of Auditory Brainstem Nuclei and Large Auditory Relay Synapses
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22661
Abstract: Large excitatory synapses are found at specific points in the neuronal circuits of the auditory brainstem, to enable fast information transfer and the preservation of acoustic timing information. The extracellular cues and signaling mechanisms that… read more here.
Keywords: bmp signaling; brainstem nuclei; bmp; auditory brainstem ... See more keywords
Tao Negatively Regulates BMP Signaling During Neuromuscular Junction Development in Drosophila
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22681
Abstract: The coordinated growth and development of synapses is critical for all aspects of neural circuit function and mutations that disrupt these processes can result in various neurological defects. Several anterograde and retrograde signaling pathways, including… read more here.
Keywords: tao; bmp signaling; tao negatively; negatively regulates ... See more keywords
Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Dynamics"
DOI: 10.1002/dvdy.229
Abstract: The epicardium is the outer mesothelial layer of the heart. It encloses the myocardium and plays key roles in heart development and regeneration. It derives from the proepicardium (PE), cell clusters that appear in the… read more here.
Keywords: notch bmp; signaling pathways; bmp signaling; heart ... See more keywords
An emerging class of new therapeutics targeting TGF, Activin, and BMP ligands in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.478
Abstract: Pulmonary arterial hypertension (PAH) is an often fatal condition, the primary pathology of which involves loss of pulmonary vascular perfusion due to progressive aberrant vessel remodeling. The reduced capacity of the pulmonary circulation places increasing… read more here.
Keywords: bmp signaling; arterial hypertension; bmp; pulmonary arterial ... See more keywords
Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole‐Exome Sequencing in a Patient with Delayed‐Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H ‐Specific Human Cellular and Zebrafish Models
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4711
Abstract: Bone morphogenetic protein (BMP) signaling is critical in skeletal development. Overactivation can trigger heterotopic ossification (HO) as in fibrodysplasia ossificans progressiva (FOP), a rare, progressive disease of massive HO formation. A small subset of FOP… read more here.
Keywords: protein bmp; bmp signaling; bone; bone morphogenetic ... See more keywords
Defining early hematopoietic‐fated primitive streak specification of human pluripotent stem cells by the orchestrated balance of Wnt, activin, and BMP signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28272
Abstract: Distinct regions of the primitive streak (PS) have diverse potential to differentiate into several tissues, including the hematopoietic lineage originated from the posterior region of PS. Although various signaling pathways have been identified to promote… read more here.
Keywords: wnt activin; signaling pathways; bmp signaling; bmp ... See more keywords
The versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-04033-z
Abstract: Blood vessels expand via sprouting angiogenesis, and this process involves numerous endothelial cell behaviors, such as collective migration, proliferation, cell–cell junction rearrangements, and anastomosis and lumen formation. Subsequently, blood vessels remodel to form a hierarchical… read more here.
Keywords: endothelial cell; cell behaviors; bmp signaling; cell ... See more keywords
BMP signaling in homeostasis, transformation and inflammatory response of intestinal epithelium
Sign Up to like & getrecommendations! Published in 2018 at "Science China Life Sciences"
DOI: 10.1007/s11427-018-9310-7
Abstract: Intestine is the organ for food digestion, nutrient absorption and pathogen defense, in which processes intestinal epithelium plays a central role. Intestinal epithelium undergoes fast turnover, and its homeostasis is regulated by multiple signaling pathways,… read more here.
Keywords: bmp signaling; signaling homeostasis; intestinal epithelium; epithelium ... See more keywords
Drosophila models of FOP provide mechanistic insight.
Sign Up to like & getrecommendations! Published in 2018 at "Bone"
DOI: 10.1016/j.bone.2017.11.001
Abstract: Fibrodysplasia ossificans progressiva (FOP) is a rare bone disease characterized by episodic events of heterotopic ossification (HO). All cases of FOP have been attributed to mutations in the ACVR1 gene that render the encoded BMP… read more here.
Keywords: drosophila; bmp signaling; drosophila models; models fop ... See more keywords
Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes in mice depending on anatomical location of the bones.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115402
Abstract: Bone morphogenetic protein (BMP) signaling in osteoblasts plays critical roles in skeletal development and bone homeostasis. Our previous studies showed loss of function of BMPR1A, one of the type 1 receptors for BMPs, in osteoblasts… read more here.
Keywords: bone; bmp signaling; bone mass; loss ... See more keywords
Energy metabolism: A newly emerging target of BMP signaling in bone homeostasis.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115467
Abstract: Energy metabolism is the process of generating energy (i.e. ATP) from nutrients. This process is indispensable for cell homeostasis maintenance and responses to varying conditions. Cells require energy for growth and maintenance and have evolved… read more here.
Keywords: homeostasis; bmp signaling; energy; bone ... See more keywords