Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling.
Sign Up to like & getrecommendations! Published in 2021 at "Angiogenesis"
DOI: 10.1007/s10456-021-09812-7
Abstract: Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure and death. Disturbed transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signalling, endothelial cell dysfunction,… read more here.
Keywords: vascular remodelling; tgf signalling; inhibition; bmp signalling ... See more keywords
BMP signalling in a mechanical context - Implications for bone biology.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115416
Abstract: Bone Morphogenetic Proteins (BMPs) are extracellular multifunctional signalling cytokines and members of the TGFβ super family. These pleiotropic growth factors crucially promote bone formation, remodeling and healing after injury. Additionally, bone homeostasis is systematically regulated… read more here.
Keywords: context; bone; biology; bmp signalling ... See more keywords
Enhanced BMP signalling causes growth plate cartilage dysrepair in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.115874
Abstract: Growth plate cartilage injuries often result in bony repair at the injury site and premature mineralization at the uninjured region causing bone growth defects, for which underlying mechanisms are unclear. With the prior microarray study… read more here.
Keywords: growth; growth plate; injury site; bmp signalling ... See more keywords
ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus
Sign Up to like & getrecommendations! Published in 2017 at "Open Biology"
DOI: 10.1098/rsob.170122
Abstract: Bone morphogenetic proteins (BMPs) play vital roles in regulating stem cell maintenance, differentiation and embryonic development. Intracellularly, BMP signalling is mediated by Smad proteins, which are regulated post-transcriptionally through reversible phosphorylation and ubiquitination. ZC4H2 is… read more here.
Keywords: xenopus; zc4h2; neural development; bmp signalling ... See more keywords
Bone morphogenetic protein signalling in pulmonary hypertension: advances and therapeutic implications
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Physiology"
DOI: 10.1113/ep086041
Abstract: What is the topic of this review? This review covers recent evidence highlighting the crucial pathophysiological roles and molecular mechanisms of the bone morphogenetic protein (BMP) signalling pathway during the progression of pulmonary hypertension (PH)… read more here.
Keywords: bone morphogenetic; morphogenetic protein; pulmonary hypertension; bmp signalling ... See more keywords
Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant
Sign Up to like & getrecommendations! Published in 2022 at "Thorax"
DOI: 10.1136/thoraxjnl-2021-218083
Abstract: Introduction Chronic lung disease, that is, bronchopulmonary dysplasia (BPD) is the most common complication in preterm infants and develops as a consequence of the misguided formation of the gas-exchange area undergoing prenatal and postnatal injury.… read more here.
Keywords: bmp; preterm; bmp signalling; pathology ... See more keywords
Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076423
Abstract: MicroRNAs (miRNAs) are a family of small, single-stranded, and non-protein coding RNAs about 19 to 22 nucleotides in length, that have been reported to have important roles in the control of bone development. MiRNAs have… read more here.
Keywords: bmp; bmp signalling; signalling cascades; canonical tgf ... See more keywords
The Epstein-Barr Virus-Encoded EBNA1 Protein Activates the Bone Morphogenic Protein (BMP) Signalling Pathway to Promote Carcinoma Cell Migration
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens"
DOI: 10.3390/pathogens9070594
Abstract: The Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) protein is expressed in all virus-associated malignancies, where it performs an essential role in the maintenance, replication and transcription of the EBV genome. In recent years, it… read more here.
Keywords: protein; carcinoma; bmp; signalling pathway ... See more keywords