The BMP‐SMAD pathway mediates the impaired hepatic iron metabolism associated with the ERFE‐A260S variant
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25613
Abstract: The erythroferrone (ERFE) is the erythroid regulator of hepatic iron metabolism by suppressing the expression of hepcidin. Congenital dyserythropoietic anemia type II (CDAII) is an inherited hyporegenerative anemia due to biallelic mutations in the SEC23B… read more here.
Keywords: hepatic iron; iron metabolism; erfe a260s; a260s variant ... See more keywords
Gremlin2 Suppression Increases the BMP‐2‐Induced Osteogenesis of Human Bone Marrow‐Derived Mesenchymal Stem Cells Via the BMP‐2/Smad/Runx2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25635
Abstract: Osteoblasts are essential for maintaining skeletal architecture and modulating bone microenvironment homeostasis. From numerous associated investigations, the BMP‐2 pathway has been well‐defined as a vital positive modulator of bone homeostasis. Gremlin2 (Grem2) is a bone… read more here.
Keywords: bmp; induced osteogenesis; bmp smad; bone ... See more keywords
Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and α-Synuclein-Induced Neurodegeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02351-8
Abstract: Parkinson's disease is a neurodegenerative disorder characterised by nigrostriatal dopaminergic degeneration, and intracellular α-synuclein aggregation. Current pharmacological treatments are solely symptomatic so there is a need to identify agents that can slow or stop dopaminergic… read more here.
Keywords: dopaminergic neurons; synuclein; quinacrine niclosamide; bmp smad ... See more keywords
Macrolactin F inhibits RANKL‐mediated osteoclastogenesis by suppressing Akt, MAPK and NFATc1 pathways and promotes osteoblastogenesis through a BMP‐2/smad/Akt/Runx2 signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.09.015
Abstract: Abstract The balance between bone formation and bone resorption is maintained by osteoblasts and osteoclasts. In the current study, macrolactin F (MF) was investigated for novel biological activity on the receptor activator of nuclear factor‐&kgr;B… read more here.
Keywords: akt; akt runx2; bmp smad; bone ... See more keywords
The effects of mouse ovarian granulosa cell function and related gene expression by suppressing BMP/Smad signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2018.1497706
Abstract: ABSTRACT BMP I type receptor inhibitor can selectively inhibit BMP/Smad signaling pathways, mainly by inhibiting the BMP I type receptor activity to prevent phosphorylation of Smad1, Smad5 and Smad9. The aim of the present study… read more here.
Keywords: ovarian granulosa; smad signaling; bmp smad; expression ... See more keywords
980nm Photobiomodulation Promotes Osteo/odontogenic Differentiation of the Stem Cells from Human Exfoliated Deciduous Teeth via the Cross-talk between BMP/Smad and Wnt/β-catenin Signaling Pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Photochemistry and photobiology"
DOI: 10.1111/php.13751
Abstract: Increasing evidence suggests stem cells from human exfoliated deciduous teeth (SHEDs) serve as desirable sources of dentin regeneration. Photobiomodulation (PBM) has shown great potential in enhancing the proliferation and osteogenesis of human bone marrow mesenchymal… read more here.
Keywords: odontogenic differentiation; bmp smad; catenin; stem cells ... See more keywords
BMP-7/Smad expression in dedifferentiated Schwann cells during axonal regeneration and upregulation of endogenous BMP-7 following administration of PTH (1-34)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Orthopaedic Surgery"
DOI: 10.1177/2309499018812953
Abstract: Purpose: To determine the expression and distribution of bone morphogenetic protein (BMP)-7 and related molecules during peripheral nerve regeneration and to assess whether administration of parathyroid hormone (PTH) drug (1-34) potentiates the intrinsic upregulation of… read more here.
Keywords: administration; bmp; regeneration; bmp smad ... See more keywords
Targeting the BMP Receptor Inhibitor FKBP12 to Upregulate Hepcidin in Wild-Type and Hemojuvelin-Hemochromatosis Models
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-126496
Abstract: Introduction Iron homeostasis is tightly regulated by the liver hormone hepcidin, whose expression is controlled by the BMP-SMAD pathway. Activation of this pathway requires ligands (BMP2 and BMP6), type I (ALK2 and ALK3) and type… read more here.
Keywords: bmp smad; expression; hepcidin; mice ... See more keywords
Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress–Activated FOXO1 to Trigger β-Cell Failure
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-0828
Abstract: Active maintenance of β-cell identity through fine-tuned regulation of key transcription factors ensures β-cell function. Tacrolimus, a widely used immunosuppressant, accelerates onset of diabetes after organ transplantation, but underlying molecular mechanisms are unclear. Here we… read more here.
Keywords: metabolic stress; smad signaling; bmp smad; tacrolimus induced ... See more keywords
Silencing of miR-330-5p stimulates osteogenesis in bone marrow mesenchymal stem cells and inhibits bone loss in osteoporosis by activating Bgn-mediated BMP/Smad pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202004_20987
Abstract: OBJECTIVE To illustrate the role of micro ribonucleic acid (miR)-330-5p in regulating osteogenesis through biglycan (Bgn)-mediated bone morphogenetic protein (BMP)/Smad pathway. MATERIALS AND METHODS A mouse model of osteoporosis (OP) was established by ovariectomy (OVX).… read more here.
Keywords: bmp smad; bgn; bgn mediated; smad pathway ... See more keywords
β-Ecdysterone Enhanced Bone Regeneration Through the BMP-2/SMAD/RUNX2/Osterix Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.883228
Abstract: Bone defects are a global public health problem. However, the available methods for inducing bone regeneration are limited. The application of traditional Chinese herbs for bone regeneration has gained popularity in recent years. β-ecdysterone is… read more here.
Keywords: bone; bmp smad; ecdysterone; bone regeneration ... See more keywords