Characterization of new bone morphogenetic protein (Bmp)‐2 regulatory alleles
Sign Up to like & getrecommendations! Published in 2017 at "genesis"
DOI: 10.1002/dvg.23035
Abstract: Bone morphogenetic protein 2 (BMP2, HGNC:1069, GeneID: 650) is a classical morphogen; a molecule that acts at a distance and whose concentration influences cell proliferation, differentiation, and apoptosis. Key events requiring precise Bmp2 regulation include… read more here.
Keywords: bmp2; bone morphogenetic; morphogenetic protein; characterization new ... See more keywords
Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice.
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.31048
Abstract: Bone morphogenetic proteins BMP2 and BMP6 play key roles in systemic iron homeostasis by regulating production of the iron hormone hepcidin. HFE also regulates hepcidin through a mechanism that intersects with the BMP-SMAD1/5/8 pathway. However,… read more here.
Keywords: hfe; bmp2; mice; bmp6 ... See more keywords
BMP2 variants in the risk of ankylosing spondylitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29563
Abstract: The purpose of the study was to explore the genetic effects of bone morphogenetic protein (BMP2) polymorphisms on the susceptibility to ankylosing spondylitis (AS) in Chinese Han population. The case‐control study included 120 AS cases… read more here.
Keywords: ankylosing spondylitis; control; bmp2 variants; bmp2 ... See more keywords
Cell trafficking and regulation of osteoblastogenesis by extracellular vesicle associated bone morphogenetic protein 2.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of extracellular vesicles"
DOI: 10.1002/jev2.12155
Abstract: Extracellular vesicles (EVs) are characterized by complex cargo composition and carry a wide array of signalling cargo, including growth factors (GFs). Beyond surface-associated GFs, it is unclear if EV intralumenal growth factors are biologically active.… read more here.
Keywords: cell trafficking; bmp2; evs; osteoblastogenesis ... See more keywords
Promotion of osteogenesis by Sweroside via BMP2‐involved signaling in postmenopausal osteoporosis
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7336
Abstract: Phlomis umbrosa has been traditionally used for bone diseases in traditional Korean Medicine. Sweroside (SOS), marker compounds of P. umbrosa, has been known to promote osteoblast differentiation. In this study, ameliorative effects of SOS on… read more here.
Keywords: bone; sweroside; saos cells; sos ... See more keywords
Expression of BMP2-Hydrophobin fusion protein in the tobacco plant and molecular dynamic evaluation of its simulated model
Sign Up to like & getrecommendations! Published in 2021 at "Plant Biotechnology Reports"
DOI: 10.1007/s11816-021-00684-3
Abstract: Plants are one of the ideal models for therapeutic protein production, however the recombinant protein purification problems in them must be overcome. Bone Morphogenetic Protein2 (BMP2) is employed for the restoration and construction of bone… read more here.
Keywords: protein; plant; purification; bmp2 ... See more keywords
Recombinant Plasmid DNA Construct Encoding Combination of vegf165 and bmp2 cDNAs Stimulates Osteogenesis and Angiogenesis In Vitro
Sign Up to like & getrecommendations! Published in 2017 at "BioNanoScience"
DOI: 10.1007/s12668-016-0300-3
Abstract: Though normally bone regenerates well, non-union, delayed union, or defective bone formation can occur. Since impaired healing is often caused by local trophic disorders, standard fracture management is often ineffective. Gene therapy is a promising… read more here.
Keywords: construct encoding; dna construct; bmp2; plasmid dna ... See more keywords
Therapeutic antibody directed osteogenic differentiation of induced pluripotent stem cell derived MSCs.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.05.028
Abstract: Induced pluripotent stem cells (iPSCs) are regarded as a new cell source for regenerative medicine. Recent advances in tissue engineering have brought to light the therapeutic application of induced pluripotent stem cells (iPSCs) in bone… read more here.
Keywords: bmp2; differentiation; pluripotent stem; osteogenic differentiation ... See more keywords
Monoallelic BMP2 Variants Predicted to Result in Haploinsufficiency Cause Craniofacial, Skeletal, and Cardiac Features Overlapping Those of 20p12 Deletions.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2017.10.006
Abstract: Bone morphogenetic protein 2 (BMP2) in chromosomal region 20p12 belongs to a gene superfamily encoding TGF-β-signaling proteins involved in bone and cartilage biology. Monoallelic deletions of 20p12 are variably associated with cleft palate, short stature,… read more here.
Keywords: bmp2 variants; short stature; bmp2; skeletal cardiac ... See more keywords
A biomimetic collagen-bone granule-heparan sulfate combination scaffold for BMP2 delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.145217
Abstract: Bone morphogenetic protein 2 (BMP2)-induced bone regeneration is most efficacious when a carrier can deliver the growth factor into the defect site while minimizing off-target effects. The control of BMP2 release by such carriers is… read more here.
Keywords: bone granule; collagen bone; heparan sulfate; bmp2 ... See more keywords
Optimized expression and purification of a soluble BMP2 variant based on in-silico design.
Sign Up to like & getrecommendations! Published in 2021 at "Protein expression and purification"
DOI: 10.1016/j.pep.2021.105918
Abstract: Bone morphogenetic protein 2 (BMP21) is a highly interesting therapeutic growth factor due to its strong osteogenic/osteoinductive potential. However, its pronounced aggregation tendency renders recombinant and soluble production troublesome and complex. While prokaryotic expression systems… read more here.
Keywords: bmp2; bmp2 2hep; expression; bmp2 variant ... See more keywords