Biointerface engineering through amalgamation of gene technology and site‐specific growth factor conjugation for efficient osteodifferentiation
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28852
Abstract: The development of bone implants through bioinspired immobilization of growth factors remains a key issue in the generation of biological interfaces, especially in enhancing osteodifferentiation ability. In this study, we developed a strategy for surface… read more here.
Keywords: site specific; growth; growth factor; bmp2 ... See more keywords
Characterization of new bone morphogenetic protein (Bmp)‐2 regulatory alleles
Sign Up to like & getrecommendations! Published in 2017 at "genesis"
DOI: 10.1002/dvg.23035
Abstract: Bone morphogenetic protein 2 (BMP2, HGNC:1069, GeneID: 650) is a classical morphogen; a molecule that acts at a distance and whose concentration influences cell proliferation, differentiation, and apoptosis. Key events requiring precise Bmp2 regulation include… read more here.
Keywords: bmp2; bone morphogenetic; morphogenetic protein; characterization new ... See more keywords
Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice.
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.31048
Abstract: Bone morphogenetic proteins BMP2 and BMP6 play key roles in systemic iron homeostasis by regulating production of the iron hormone hepcidin. HFE also regulates hepcidin through a mechanism that intersects with the BMP-SMAD1/5/8 pathway. However,… read more here.
Keywords: hfe; bmp2; mice; bmp6 ... See more keywords
BMP2 variants in the risk of ankylosing spondylitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29563
Abstract: The purpose of the study was to explore the genetic effects of bone morphogenetic protein (BMP2) polymorphisms on the susceptibility to ankylosing spondylitis (AS) in Chinese Han population. The case‐control study included 120 AS cases… read more here.
Keywords: ankylosing spondylitis; control; bmp2 variants; bmp2 ... See more keywords
Cell trafficking and regulation of osteoblastogenesis by extracellular vesicle associated bone morphogenetic protein 2.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of extracellular vesicles"
DOI: 10.1002/jev2.12155
Abstract: Extracellular vesicles (EVs) are characterized by complex cargo composition and carry a wide array of signalling cargo, including growth factors (GFs). Beyond surface-associated GFs, it is unclear if EV intralumenal growth factors are biologically active.… read more here.
Keywords: cell trafficking; bmp2; evs; osteoblastogenesis ... See more keywords
Promotion of osteogenesis by Sweroside via BMP2‐involved signaling in postmenopausal osteoporosis
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7336
Abstract: Phlomis umbrosa has been traditionally used for bone diseases in traditional Korean Medicine. Sweroside (SOS), marker compounds of P. umbrosa, has been known to promote osteoblast differentiation. In this study, ameliorative effects of SOS on… read more here.
Keywords: bone; sweroside; saos cells; sos ... See more keywords
Targeted Delivery of Exosomal Bmp2 mRNA via a Bioadhesive Interface Synergistically Enhances Titanium Implant Osseointegration.
Sign Up to like & getrecommendations! Published in 2025 at "Small"
DOI: 10.1002/smll.202510386
Abstract: Rapid osseointegration of titanium implants remains challenging under pathological conditions. This study develops an engineered exosome-based mRNA delivery system for osteogenic regulation. Through co-transfection with BMP2 and Paip2 plasmids, Exosomes (Exoen) loaded with untranslated Bmp2 mRNA are… read more here.
Keywords: titanium; mrna; bmp2 mrna; delivery ... See more keywords
Expression of BMP2-Hydrophobin fusion protein in the tobacco plant and molecular dynamic evaluation of its simulated model
Sign Up to like & getrecommendations! Published in 2021 at "Plant Biotechnology Reports"
DOI: 10.1007/s11816-021-00684-3
Abstract: Plants are one of the ideal models for therapeutic protein production, however the recombinant protein purification problems in them must be overcome. Bone Morphogenetic Protein2 (BMP2) is employed for the restoration and construction of bone… read more here.
Keywords: protein; plant; purification; bmp2 ... See more keywords
Engineering a BMP2–risedronate complex with sustained release for osteoporosis therapy
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-025-01568-8
Abstract: Human bone morphogenetic protein 2 (BMP2) is a key inducer of osteogenesis; however, conventional delivery systems often result in burst release and adverse effects. To address this limitation, we fabricated an ionic complex of BMP2… read more here.
Keywords: risedronate complex; release; bmp2 risedronate; bmp2 ... See more keywords
Recombinant Plasmid DNA Construct Encoding Combination of vegf165 and bmp2 cDNAs Stimulates Osteogenesis and Angiogenesis In Vitro
Sign Up to like & getrecommendations! Published in 2017 at "BioNanoScience"
DOI: 10.1007/s12668-016-0300-3
Abstract: Though normally bone regenerates well, non-union, delayed union, or defective bone formation can occur. Since impaired healing is often caused by local trophic disorders, standard fracture management is often ineffective. Gene therapy is a promising… read more here.
Keywords: construct encoding; dna construct; bmp2; plasmid dna ... See more keywords
Therapeutic antibody directed osteogenic differentiation of induced pluripotent stem cell derived MSCs.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.05.028
Abstract: Induced pluripotent stem cells (iPSCs) are regarded as a new cell source for regenerative medicine. Recent advances in tissue engineering have brought to light the therapeutic application of induced pluripotent stem cells (iPSCs) in bone… read more here.
Keywords: bmp2; differentiation; pluripotent stem; osteogenic differentiation ... See more keywords