Bone morphogenetic protein 4 regulates immortalized chicken preadipocyte proliferation by promoting G1/S cell cycle progression
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12640
Abstract: Bone morphogenetic protein 4 (BMP4) has been reported to regulate adipose development, but its role in preadipocyte proliferation has not been explored in vitro. Here, we investigated the effect of BMP4 on chicken preadipocyte proliferation… read more here.
Keywords: cell cycle; bmp4; preadipocyte proliferation; proliferation ... See more keywords
Endothelial BMP4 Promotes Leukocyte Rolling and Adhesion and Is Elevated in Patients After Survived Out-of-Hospital Cardiac Arrest
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01307-9
Abstract: Leukocyte recruitment is a fundamental step in the inflammatory response during ischemia/reperfusion injury (IRI). Rolling and adhesion of leukocytes to activated endothelium promote tissue inflammation after IRI and require presentation of adhesion molecules E-selectin and… read more here.
Keywords: bmp4 mice; rolling adhesion; endothelial bmp4; adhesion ... See more keywords
Up-regulation of miR-340-5p promotes progression of thyroid cancer by inhibiting BMP4
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-018-0848-6
Abstract: PurposeThe incidence of thyroid cancer is increasing and the proliferation of thyroid cancer cells is incompletely understood. microRNAs may play key roles in thyroid cancer progression.MethodsWe analyzed miR-340-5p in thyroid cancer tissue and normal tissue,… read more here.
Keywords: thyroid cancer; 340 promotes; bmp4; cancer ... See more keywords
The Role of Bone Morphogenetic Protein 4 in Ovarian Function and Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive Sciences"
DOI: 10.1007/s43032-021-00600-8
Abstract: Bone morphogenetic proteins (BMPs) are the largest subfamily of the transforming growth factor-β (TGF-β) superfamily. BMP4 is a secreted protein that was originally identified due to its role in bone and cartilage development. Over the… read more here.
Keywords: role bone; bone; bone morphogenetic; role ... See more keywords
BMP4 mutations in tooth agenesis and low bone mass.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2019.05.012
Abstract: OBJECTIVE To identify an uncommon genetic cause of tooth agenesis (TA) by utilizing whole exome sequencing (WES) and targeted Sanger sequencing in a cohort of 120 patients with isolated TA. DESIGN One deleterious mutation in… read more here.
Keywords: tooth agenesis; mutations tooth; bmp4; bmp4 mutations ... See more keywords
Epigenetic modification cooperates with Zeb1 transcription factor to regulate Bmp4 to promote chicken PGCs formation.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145760
Abstract: BMP4 is the critical gene of primordial germ cell formation in mammal, however, the mechanism of PGCs formation in chicken still unknown. In this research, we compared the evolution relationship of different species. Although the… read more here.
Keywords: transcription; pgcs formation; formation; expression ... See more keywords
BMP4/Id2 signaling pathway is a novel therapeutic target for late outgrowth endothelial progenitor cell-mediated endothelial injury repair.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2016.11.027
Abstract: BACKGROUND Endothelial progenitor cells (EPCs) play a pivotal role in endothelial repair following artery injury, however, the molecular mechanism of late outgrowth EPCs (LEPCs) in endothelial repair remained to be studied. Bone morphogenetic protein 4… read more here.
Keywords: lepcs; signaling pathway; bmp4; endothelial repair ... See more keywords
GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stem Cell"
DOI: 10.1016/j.stem.2020.03.005
Abstract: Summary During early development, extrinsic triggers prompt pluripotent cells to begin the process of differentiation. When and how human embryonic stem cells (hESCs) irreversibly commit to differentiation is a fundamental yet unanswered question. By combining… read more here.
Keywords: differentiation human; commitment; differentiation; bmp4 ... See more keywords
BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00435-x
Abstract: Alzheimer’s disease (AD) is a chronic progressive degenerative disease of the nervous system. Its pathogenesis is complex and is related to the abnormal expression of the amyloid β (Aβ), APP, and Tau proteins. Evidence has… read more here.
Keywords: bmp4 overexpression; alzheimer disease; bmp4; disease ... See more keywords
187 Phenotype switch of human fibroblasts into trophoblastic cells
Sign Up to like & getrecommendations! Published in 2019 at "Reproduction, Fertility and Development"
DOI: 10.1071/rdv31n1ab187
Abstract: The first differentiation event in mammalian embryos is the formation of the trophectoderm, which is crucial for implantation of the blastocyst and gives rise to specialised populations of trophoblast cells in the definitive placenta. However,… read more here.
Keywords: differentiation; fibroblasts trophoblastic; human fibroblasts; trophoblastic cells ... See more keywords
Inhibition of BMP4 alleviates diabetic retinal vascular dysfunction via the VEGF and smad1/5 signalling.
Sign Up to like & getrecommendations! Published in 2023 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2023.2190054
Abstract: Objective:The aim of our study was to determine the molecular mechanism of BMP4 (bone morphogenetic protein 4) in DR (diabetic retinopathy).Methods: Human retinal endothelial cell (HRECs) induced by high glucose to simulate one of the… read more here.
Keywords: vegf; diabetic retinopathy; bmp4 could; inhibition bmp4 ... See more keywords