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   Articles with "bmp6" as a keyword



Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice.

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recommendations! Published in 2019 at "Hepatology"

DOI: 10.1002/hep.31048

Abstract: Bone morphogenetic proteins BMP2 and BMP6 play key roles in systemic iron homeostasis by regulating production of the iron hormone hepcidin. HFE also regulates hepcidin through a mechanism that intersects with the BMP-SMAD1/5/8 pathway. However,… read more here.

Keywords: hfe; bmp2; mice; bmp6 ... See more keywords

Effect of Bone Morphogenetic Protein 6 on Immunomodulatory Functions of Salivary Gland-Derived Mesenchymal Stem Cells in Sjögren's Syndrome.

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recommendations! Published in 2018 at "Stem cells and development"

DOI: 10.1089/scd.2017.0161

Abstract: Sjögren's syndrome (SS) is characterized by autoimmune activation and loss of function in the salivary glands. Recent studies reported that bone morphogenetic protein 6 (BMP6), which is a member of transforming growth factor beta (TGF-β)… read more here.

Keywords: stem cells; salivary gland; gren syndrome; bmp6 ... See more keywords

Dual delivery of platelet-derived growth factor and bone morphogenetic factor-6 on titanium surface to enhance the early period of implant osseointegration.

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recommendations! Published in 2020 at "Journal of periodontal research"

DOI: 10.1111/jre.12756

Abstract: OBJECTIVE To test the surface properties and in vitro effects of a new sequential release system on MC3T3-E1 cells for improved osseointegration. BACKGROUND BMP6-loaded anodized titanium coated with PDGF containing silk fibroin (SF) may improve… read more here.

Keywords: titanium; bmp6; osseointegration; factor ... See more keywords

Anticeramide Improves Sjögren’s Syndrome by Blocking BMP6-Induced Th1

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recommendations! Published in 2022 at "Journal of Dental Research"

DOI: 10.1177/00220345221119710

Abstract: T-cell dysfunction has been shown to play an important role in the pathogenesis of Sjögren’s syndrome (SS). In recent studies, the increased expression of BMP6 has been reported to be related to SS. However, the… read more here.

Keywords: cd4 cells; gren syndrome; bmp6; syndrome blocking ... See more keywords

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood-2016-06-721571

Abstract: Bone morphogenetic protein 6 (BMP6) signaling in hepatocytes is a central transcriptional regulator of the iron hormone hepcidin that controls systemic iron balance. How iron levels are sensed to regulate hepcidin production is not known,… read more here.

Keywords: iron homeostasis; bone morphogenetic; mice; bmp6 ... See more keywords

Liver sinusoidal endothelial cells induce BMP6 expression in response to non-transferrin bound iron.

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recommendations! Published in 2022 at "Blood"

DOI: 10.1182/blood.2022016987

Abstract: Homeostatic adaptation to systemic iron overload involves transcriptional induction of bone morphogenetic protein 6 (BMP6) in liver sinusoidal endothelial cells (LSECs). BMP6 is then secreted to activate signaling to the iron hormone hepcidin (HAMP) in… read more here.

Keywords: liver sinusoidal; sinusoidal endothelial; transferrin; bmp6 ... See more keywords

Investigation of the Mechanism of SEMA5A and Its Associated Autophagy-Related Genes in Gastric Cancer

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recommendations! Published in 2024 at "International Journal of General Medicine"

DOI: 10.2147/ijgm.s471370

Abstract: Purpose Semaphorin 5A (SEMA5A) and autophagy-related genes (ARGs) are pivotal in the pathogenesis of gastric cancer (GC). However, the potential regulatory role of SEMA5A in autophagy via its associated ARGs and the underlying molecular mechanisms… read more here.

Keywords: cancer; related genes; analysis; autophagy related ... See more keywords

The Influence of BMP6 on Serotonin and Glucose Metabolism

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms25147842

Abstract: Previous studies have suggested a potential role of bone morphogenetic protein 6 (BMP6) in glucose metabolism, which also seems to be regulated by serotonin (5-hydroxytryptamine, 5HT), a biogenic amine with multiple roles in the organism.… read more here.

Keywords: glucose metabolism; bmp6 serotonin; bmp6; metabolism ... See more keywords