An easy long‐acting BMP7 release system based on biopolymer nanoparticles for inducing osteogenic differentiation of adipose mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.3070
Abstract: In contrast to the early acting bone morphogenetic protein 2, bone morphogenetic protein 7 (BMP7) plays a decisive role mainly in the late stages of bone formation. To overcome deactivation and degradation of expensive BMP7,… read more here.
Keywords: bmp7 release; long acting; osteogenic differentiation; bmp7 ... See more keywords
Protection of tubular epithelial cells during renal injury via post-transcriptional control of BMP7
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3063-4
Abstract: Severe injury of renal tubular epithelial cells may cause acute renal failure, the progression of which results in renal fibrosis, and obstructive nephropathy. Transforming growth factor β 1 and bone morphogenic protein 7 (BMP7) play… read more here.
Keywords: epithelial cells; mir 384; renal injury; tubular epithelial ... See more keywords
BMP7 reduces the fibrocartilage chondrocyte phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-99096-0
Abstract: The fibrocartilage chondrocyte phenotype has been recognized to attribute to osteoarthritis (OA) development. These chondrocytes express genes related to unfavorable OA outcomes, emphasizing its importance in OA pathology. BMP7 is being explored as a potential… read more here.
Keywords: bmp7; protein levels; activity; chondrocyte phenotype ... See more keywords
Ultrasound triggered topical delivery of Bmp7 mRNA for white fat browning induction via engineered smart exosomes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-021-01145-3
Abstract: Background Efficient and topical delivery of drugs is essential for maximized efficacy and minimized toxicity. In this study, we aimed to design an exosome-based drug delivery platform endowed with the ability of escaping from phagocytosis… read more here.
Keywords: bmp7 mrna; delivery; smartexo; engineered smart ... See more keywords
BMP7 increases protein synthesis in SW1353 cells and determines rRNA levels in a NKX3-2-dependent manner
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263430
Abstract: BMP7 is a morphogen capable of counteracting the OA chondrocyte hypertrophic phenotype via NKX3-2. NKX3-2 represses expression of RUNX2, an important transcription factor for chondrocyte hypertrophy. Since RUNX2 has previously been described as an inhibitor… read more here.
Keywords: transcription; bmp7; sw1353 cells; 47s gene ... See more keywords
Up-regulation of Bone Morphogenetic Protein 7 by 2-Hydroxycinnamaldehyde Attenuates HNSCC Cell Invasion
Sign Up to like & getrecommendations! Published in 2018 at "AntiCancer Research"
DOI: 10.21873/anticanres.12913
Abstract: Background/Aim: Few studies have examined the effect of 2’-hydroxycinnamaldehyde (HCA) on head and neck squamous cell carcinoma (HNSCC) cell invasion. This study examined the role of BMP7 on the anti-migration and anti-invasion activity of HCA… read more here.
Keywords: hnscc cell; invasion; cell invasion; hca ... See more keywords
Molecular Characterization and Function of Bone Morphogenetic Protein 7 (BMP7) in the Pacific Abalone, Haliotis discus hannai
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14061128
Abstract: Bone morphogenetic proteins (BMPs) play important roles in a lot of biological processes, such as bone development, cell proliferation, cell differentiation, growth, etc. However, the functions of abalone BMP genes are still unknown. This study… read more here.
Keywords: haliotis discus; bmp7; hdh bmp7; bone morphogenetic ... See more keywords
Role of Bone Morphogenetic Protein 7 (BMP7) in the Modulation of Corneal Stromal and Epithelial Cell Functions
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19051415
Abstract: In the cornea, healing of the wounded avascular surface is an intricate process comprising the involvement of epithelial, stromal and neuronal cell interactions. These interactions result to the release of various growth factors that play… read more here.
Keywords: epithelial cells; corneal; growth; expression ... See more keywords
Initial Harm Reduction by N-Acetylcysteine Alleviates Cartilage Degeneration after Blunt Single-Impact Cartilage Trauma in Vivo
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20122916
Abstract: Joint injuries are highly associated with the development of post-traumatic osteoarthritis. Previous studies revealed cell- and matrix-protective effects of N-acetylcysteine (NAC) after ex vivo cartilage trauma, while chondroanabolic stimulation with bone morphogenetic protein 7 (BMP7)… read more here.
Keywords: harm reduction; cartilage trauma; bmp7; cartilage ... See more keywords
Engineering of a Long-Acting Bone Morphogenetic Protein-7 by Fusion with Albumin for the Treatment of Renal Injury
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14071334
Abstract: The bone morphogenetic protein-7 (BMP7) is capable of inhibiting TGF-β/Smad3 signaling, which subsequently results in protecting the kidney from renal fibrosis, but its lower blood retention and osteogenic activity are bottlenecks for its clinical application.… read more here.
Keywords: hsa bmp7; bmp7; bone morphogenetic; treatment renal ... See more keywords
BMP7 mediates the anticancer effect of honokiol by upregulating p53 in HCT116 cells.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of oncology"
DOI: 10.3892/ijo.2017.4078
Abstract: Colorectal cancer (CRC) is the second leading cause of cancer death. Hence, there is a great need to explore new efficacious drugs for the treatment of CRC. Honokiol (HNK), a natural product extracted from magnolia… read more here.
Keywords: anticancer effect; p53; cancer; hnk ... See more keywords