BMP9‐ID1 signaling promotes EpCAM‐positive cancer stem cell properties in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12963
Abstract: The malignant nature of hepatocellular carcinoma (HCC) is closely related to the presence of cancer stem cells (CSCs). Bone morphologic protein 9 (BMP9), a member of the transforming growth factor‐beta (TGF‐β) superfamily, was recently reported… read more here.
Keywords: epcam positive; hcc; id1 signaling; cancer ... See more keywords
BMP9 Reduces Bone Loss in Ovariectomized Mice by Dual Regulation of Bone Remodeling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3957
Abstract: Bone remodeling is dynamic and is tightly regulated through bone resorption dominated by osteoclasts and bone formation dominated by osteoblasts. Imbalances in this process can cause various pathological conditions, such as osteoporosis. Bone morphogenetic protein… read more here.
Keywords: bmp9; bone; bone loss; bone remodeling ... See more keywords
HIF‐1α plays an essential role in BMP9‐mediated osteoblast differentiation through the induction of a glycolytic enzyme, PDK1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30752
Abstract: Bone homeostasis is regulated by bone morphogenic proteins (BMPs), among which BMP9 is one of the most osteogenic. Here, we have found that BMP9 rapidly increases the protein expression of hypoxia‐inducible factor‐1α (HIF‐1α) in osteoblasts… read more here.
Keywords: pdk1; hif protein; expression; hif ... See more keywords
Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Angiogenesis"
DOI: 10.1007/s10456-020-09741-x
Abstract: Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are postulated to favor a pathological pulmonary endothelial cell (EC) phenotype in pulmonary arterial hypertension (PAH). BMP9 is shown to reinstate BMP receptor… read more here.
Keywords: arterial hypertension; pulmonary ecs; pulmonary arterial; pah ... See more keywords
Identification of novel ALK2 inhibitors and their effect on cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.016
Abstract: Bone morphogenetic protein 9 (BMP9), a member of the TGF-β superfamily, is considered a regulator of glucose homeostasis as well as a neuronal differentiation factor. BMP9 induces phosphorylation of Smad1/5 through activin receptor-like kinase 1… read more here.
Keywords: alk2 inhibitors; novel alk2; identification novel; cancer cells ... See more keywords
Release of VEGF and BMP9 from injectable alginate based composite hydrogel for treatment of myocardial infarction
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2020.08.031
Abstract: Myocardial infarction (MI) is one of cardiovascular diseases that pose a serious threat to human health. The pathophysiology of MI is complex and contains several sequential phases including blockage of a coronary artery, necrosis of… read more here.
Keywords: composite hydrogel; vegf bmp9; release vegf; infarction ... See more keywords
BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107591
Abstract: Our previous study confirmed that bone morphogenetic protein 9 (BMP9) participated in the development of nonalcoholic steatohepatitis (NASH) by affecting macrophage polarization. The focus of this study was to further confirm the role of macrophages… read more here.
Keywords: nonalcoholic steatohepatitis; methionine choline; macrophage polarization; macrophage ... See more keywords
Dentinogenesis and Tooth-Alveolar Bone Complex Defects in BMP9/GDF2 Knockout Mice
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells and Development"
DOI: 10.1089/scd.2018.0230
Abstract: Tooth development is regulated by sequential and reciprocal epithelium-mesenchymal interactions and their related molecular signaling pathways, such as bone morphogenetic proteins (BMPs). Among the 14 types of BMPs, BMP9 (also known as growth differentiation factor… read more here.
Keywords: bone; tooth development; mice; dentinogenesis ... See more keywords
Leptin Potentiates BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Through the Activation of JAK/STAT Signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cells and development"
DOI: 10.1089/scd.2019.0292
Abstract: Mesenchymal stem cells (MSCs) are multipotent progenitors that have the ability to differentiate into multiple lineages including bone, cartilage, and fat. We previously demonstrated that the least known BMP9 (also known as GDF2) is one… read more here.
Keywords: leptin; bmp9 induced; osteogenic differentiation; stem cells ... See more keywords
CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARα expression
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abc5022
Abstract: Hepatic cytokine BMP9 attenuates fatty liver by regulating the key lipid metabolism factor PPARα. Obesity drives the development of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steatosis. Several bone morphogenetic proteins (BMPs) except BMP9… read more here.
Keywords: ppar; liver steatosis; mediated bmp9; ppar expression ... See more keywords
HIF1α Promotes BMP9-Mediated Osteoblastic Differentiation and Vascularization by Interacting with CBFA1
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/2475169
Abstract: Bone morphogenetic protein 9 (BMP9) as the most potent osteogenic molecule which initiates the differentiation of stem cells into the osteoblast lineage and regulates angiogenesis, remains unclear how BMP9-regulated angiogenic signaling is coupled to the… read more here.
Keywords: hif1; bmp9; differentiation; angiogenic differentiation ... See more keywords