Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers.
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DOI: 10.1016/j.stem.2016.08.019
Abstract: In familial pulmonary arterial hypertension (FPAH), the autosomal dominant disease-causing BMPR2 mutation is only 20% penetrant, suggesting that genetic variation provides modifiers that alleviate the disease. Here, we used comparison of induced pluripotent stem cell-derived endothelial… read more here.
Keywords: mutation carriers; bmpr2 mutation; ipsc ecs; endothelial cells ... See more keywords