HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling.
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DOI: 10.1016/j.vph.2018.12.006
Abstract: High mobility group box 1 (HMGB1), a critical nonclassical inflammatory cytokine, has been found up-regulated in patients with idiopathic pulmonary arterial hypertension (IPAH), but its role in vascular remodeling of pulmonary hypertension (PH) is still… read more here.
Keywords: hmgb1 tlr4; pulmonary hypertension; hypertension; bmpr2 signaling ... See more keywords
A11385 ADAR1 is a critical downstream effector of BMPR2 signaling in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548246.43979.8b
Abstract: Objectives: Pulmonary arterial hypertension (PAH) is a fatal disease which is characterized by pulmonary artery endothelial cell (PAEC) dysfunction and occlusive vascular remodeling. Activated bone morphogenetic protein type 2 receptor (BMPR2) signaling plays a key… read more here.
Keywords: bmpr2 signaling; pulmonary arterial; expression; hypertension ... See more keywords