Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis
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DOI: 10.1038/s41598-018-34830-9
Abstract: Activation of NF-κB signaling promotes osteoarthritis (OA) through the transcriptional induction of Hif-2α and catabolic enzymes. This study sought to examine whether inhibiting IκBα kinase (IKK) could suppress the development of surgically-induced OA of the… read more here.
Keywords: articular administration; intra articular; bms 345541; hif axis ... See more keywords