Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2.
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DOI: 10.1021/acsmedchemlett.1c00082
Abstract: To improve the metabolic stability profile of BMS-741672 (1a), we undertook a structure-activity relationship study in our trisubstituted cyclohexylamine series. This ultimately led to the identification of 2d (BMS-753426) as a potent and orally bioavailable… read more here.
Keywords: potent orally; orally bioavailable; bms 753426; bioavailable antagonist ... See more keywords