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Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants to Guide Therapeutic Dosing

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Published in 2020 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.784

Abstract: BMS‐986184 is a human, second‐generation, anti–interferon‐γ–induced protein 10 (IP‐10) monoclonal antibody. In this study the pharmacokinetics and target engagement (TE) of BMS‐986184 in healthy participants were characterized using population‐based target‐mediated drug disposition (TMDD) modeling and… read more here.

Keywords: bms 986184; healthy participants; interferon induced; pharmacokinetics target ... See more keywords