Bioactive Silk Fibroin Hydrogel Harnesses BMSCs‐EVs to Modulate Inflammatory Microenvironment in Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.70159
Abstract: ABSTRACT Intervertebral disc degeneration (IVDD) is a common age‐related disorder associated with inflammation, pain and impaired mobility. In this study, we developed a therapeutic system using silk fibroin (SF) hydrogel loaded with mRNA‐engineered extracellular vesicles… read more here.
Keywords: disc degeneration; intervertebral disc; hydrogel; silk fibroin ... See more keywords
Ameliorative Effects of Extracellular Vesicles Derived from Mesenchymal Stem Cells on Apoptosis and Differentiation of Osteoblasts Treated with CoCl2.
Sign Up to like & getrecommendations! Published in 2023 at "Cellular reprogramming"
DOI: 10.1089/cell.2023.0001
Abstract: Severe osteoporotic fracture occurring in sites with inadequate blood supply can cause irreversible damage to cells, particularly osteoblasts, with current drug and surgical interventions exhibiting limitations for elderly individuals. As participants mediating intercellular communication, extracellular… read more here.
Keywords: extracellular vesicles; mesenchymal stem; cocl2; differentiation ... See more keywords