Health‐related quality of life in reduced‐intensity hematopoietic cell transplantation based on donor availability in patients aged 50–75 with advanced myelodysplastic syndrome: BMT CTN 1102
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DOI: 10.1002/ajh.26768
Abstract: For myelodysplastic syndrome (MDS), allogeneic hematopoietic cell transplantation (alloHCT) is the only available curative therapy. The Blood and Marrow Transplant Clinical Trials Network study 1102 (BMT CTN 1102, NCT02016781) was a multicenter, biologic assignment trial… read more here.
Keywords: donor availability; bmt ctn; cell transplantation; availability ... See more keywords
Long-Term Follow up of BMT CTN 0901, a Randomized Phase III Trial Comparing Myeloablative (MAC) to Reduced Intensity Conditioning (RIC) Prior to Hematopoietic Cell Transplantation (HCT) for Acute Myeloid Leukemia (AML) or Myelodysplasia (MDS) (MAvRIC Trial)
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DOI: 10.1016/j.bbmt.2019.12.075
Abstract: BMT CTN 0901 enrolled patients with MDS (N=54) or AML (N=218) (median age of 55 years) who had Overall survival (OS) at 4 years was 65% and 49% for MAC and RIC (p=0.02), respectively. In… read more here.
Keywords: trial; bmt ctn; ctn 0901; long term ... See more keywords
Analysis of BMT CTN-0201 and -0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD
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DOI: 10.1038/s41409-018-0331-1
Abstract: Regenerating islet-derived protein 3 alpha (REG3A) is a C-type lectin constitutively expressed and apically secreted by Paneth cells at high levels, with powerful bactericidal activity against gram-positive bacteria of the gut [1]. By limiting the… read more here.
Keywords: bmt ctn; ctn 0201; association; gvhd ... See more keywords
Amphiregulin modifies the Minnesota Acute Graft-versus-Host Disease Risk Score: results from BMT CTN 0302/0802.
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DOI: 10.1182/bloodadvances.2018017343
Abstract: Amphiregulin (AREG) is an epidermal growth factor receptor ligand that can restore integrity to damaged intestinal mucosa in murine models of acute graft-versus-host disease (aGVHD). We previously reported that circulating AREG is elevated in late-onset… read more here.
Keywords: risk; bmt ctn; versus host; host disease ... See more keywords