HIV vaccines in 2022: where to from here?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25923
Abstract: The way forward requires all stakeholders—funders, researchers, product developers, trial networks and advocates—to analyse closely what the field has learned to date, develop clarity on the critical scientific challenges and agree on a coordinated strategy… read more here.
Keywords: hiv vaccines; vaccines 2022; hiv; bnab ... See more keywords
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aay7199
Abstract: Engineering better bnAbs A highly effective HIV vaccine has been the goal of vaccinologists for nearly 35 years. A successful vaccine would need to induce broadly neutralizing antibodies (bnAbs) that are capable of neutralizing multiple… read more here.
Keywords: improbable mutations; hiv; antibody; vaccine ... See more keywords
A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03370-22
Abstract: An effective HIV-1 vaccination strategy will need to stimulate rare precursor B cells of multiple bNAb lineages and affinity mature them along desired pathways. Here, we searched for V2-apex germ line-targeting Envs among a large… read more here.
Keywords: apex; bnab; chimpanzee siv; precursor ... See more keywords