Future of bNAbs in HIV Treatment
Sign Up to like & getrecommendations! Published in 2025 at "Current HIV/AIDS Reports"
DOI: 10.1007/s11904-025-00744-1
Abstract: Broadly neutralizing antibodies (bNAbs) represent a novel approach to HIV treatment, prevention, and cure strategies. As research advances, the clinical application of bNAbs continues to evolve. This review explores the potential role of bNAbs in… read more here.
Keywords: hiv; bnabs; future bnabs; bnabs hiv ... See more keywords
Hyaluronidase-enhanced subcutaneous delivery of bNAbs: a phase 1 randomized controlled clinical trial in HIV-uninfected women
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63051-8
Abstract: Broadly neutralizing antibodies (bNAbs) offer a promising strategy for HIV prevention. Subcutaneous (SC) administration is more feasible than intravenous delivery but may be limited by prolonged administration times and multiple injections. Here we report a… read more here.
Keywords: hiv; hyaluronidase enhanced; bnabs; trial ... See more keywords
Broadly neutralizing HIV-1 antibody reactivity in HIV tests: implications for diagnostics.
Sign Up to like & getrecommendations! Published in 2021 at "AIDS"
DOI: 10.1097/qad.0000000000002898
Abstract: OBJECTIVE Passive immunization with broadly neutralizing antibodies (bNAbs) is under evaluation for HIV prevention. BNAbs target gp120 or gp41, two HIV envelope antigens commonly present in diagnostic tests. Depending on bNAb type and dose administered… read more here.
Keywords: broadly neutralizing; hiv; hiv tests; bnabs ... See more keywords
An HIV-1 Broadly Neutralizing Antibody from a Clade C-Infected Pediatric Elite Neutralizer Potently Neutralizes the Contemporaneous and Autologous Evolving Viruses
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01495-18
Abstract: More than 50% of the HIV-1 infections globally are caused by clade C viruses. To date, there is no effective vaccine to prevent HIV-1 infection. Based on the structural information of the currently available HIV-1… read more here.
Keywords: elite neutralizer; hiv; aiims p01; pediatric elite ... See more keywords
Positive Selection at Key Residues in the HIV Envelope Distinguishes Broad and Strain-Specific Plasma Neutralizing Antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01685-18
Abstract: Millions of people are still being infected with HIV decades after the first recognition of the virus. Currently, no vaccine is able to elicit bNAbs that will prevent infection by global HIV strains. Several studies… read more here.
Keywords: evolution; diversity; hiv; strain specific ... See more keywords
Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1006235
Abstract: Broadly-neutralizing monoclonal antibodies (bNAbs) may guide vaccine development for highly variable viruses including hepatitis C virus (HCV), since they target conserved viral epitopes that could serve as vaccine antigens. However, HCV resistance to bNAbs could… read more here.
Keywords: hcv; resistance; hepatitis virus; receptor ... See more keywords
Glycoengineering HIV-1 Env creates ‘supercharged’ and ‘hybrid’ glycans to increase neutralizing antibody potency, breadth and saturation
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007024
Abstract: The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb). Consequently, most bnAbs must inevitably make some glycan contacts and avoid clashes with others. To… read more here.
Keywords: sensitivity; hybrid glycans; saturation; bnabs ... See more keywords