The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone‐induced death, through the NGF receptor TrkA
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DOI: 10.1002/glia.23170
Abstract: BNN27, a member of a chemical library of C17‐spiroepoxy derivatives of the neurosteroid DHEA, has been shown to regulate neuronal survival through its selective interaction with NGF receptors (TrkA and p75NTR), but its role on… read more here.
Keywords: cuprizone; novel synthetic; mature oligodendrocytes; ngf ... See more keywords
The Synthetic Microneurotrophin BNN27 Affects Retinal Function in Rats With Streptozotocin-Induced Diabetes
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DOI: 10.2337/db17-0391
Abstract: BNN27, a C17-spiroepoxy derivative of DHEA, was shown to have antiapoptotic properties via mechanisms involving the nerve growth factor receptors (tropomyosin-related kinase A [TrkA]/neurotrophin receptor p75 [p75NTR]). In this study, we examined the effects of… read more here.
Keywords: microneurotrophin bnn27; synthetic microneurotrophin; function; diabetes synthetic ... See more keywords