Preparation of benznidazole pellets for immediate drug delivery using the extrusion spheronization technique
Sign Up to like & getrecommendations! Published in 2017 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2016.1220574
Abstract: Abstract Recent advances in the treatment of Chagas disease have followed combinations of drugs that act synergistically against infection, predominantly including benznidazole (BNZ) and azoles derivatives. Possible incompatibilities between these drugs, slow dissolution of BNZ… read more here.
Keywords: using extrusion; immediate drug; sodium; drug ... See more keywords
Dried Blood Spot Technique-Based Liquid Chromatography-Tandem Mass Spectrometry Method as a Simple Alternative for Benznidazole Pharmacokinetic Assessment
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00845-18
Abstract: Chagas disease (CD) is recognized as one of the major neglected global tropical diseases. Benznidazole (BNZ) is the drug of choice for the treatment of adults, young infants, and newborns with CD. ABSTRACT Chagas disease… read more here.
Keywords: method; dried blood; bnz; liquid chromatography ... See more keywords
Benznidazole in Cerebrospinal Fluid: a Case Series of Chagas Disease Meningoencephalitis in HIV-Positive Patients
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01922-20
Abstract: Chagas disease reactivation in HIV-positive people is an opportunistic infection with 79 to 100% mortality. It commonly involves the central nervous system (CNS). ABSTRACT Chagas disease reactivation in HIV-positive people is an opportunistic infection with… read more here.
Keywords: hiv positive; bnz; csf; chagas disease ... See more keywords
Co-Inhibition of IL-2, IL-9 and IL-15 By the Novel Immunomodulator, Bnz-1, Provides Clinical Efficacy in Patients with Refractory Cutaneous T Cell Lymphoma in a Phase 1/2 Clinical Trial
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DOI: 10.1182/blood-2020-143135
Abstract: Background: Cutaneous T cell lymphoma is incurable with current standard therapies and there is an urgent need for more effective therapies. BNZ-1 is a pegylated peptide antagonist that binds to the common gamma chain signaling… read more here.
Keywords: bnz; efficacy; consultancy; research funding ... See more keywords
IL-1ß, IL-6 and TNF-α expression levels of macrophage cells induced by benzydamine hydrochloride, benzydamine hydrochloride with chitosan, calcium hydroxide and chlorhexidine medicaments: An ELISA study.
Sign Up to like & getrecommendations! Published in 2022 at "Dental materials journal"
DOI: 10.4012/dmj.2021-265
Abstract: The aim of the present study was to evaluate IL-1ß, IL-6 and TNF-α expression levels of macrophage cells induced by benzydamine hydrochloride (BNZ), BNZ with chitosan, calcium hydroxide (CH) and chlorhexidine (CHX) medicaments. Half maximal… read more here.
Keywords: tnf expression; benzydamine hydrochloride; bnz; expression levels ... See more keywords