Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementia
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51482
Abstract: Parkinson disease (PD) is defined by the accumulation of misfolded α‐synuclein (α‐syn) in Lewy bodies and Lewy neurites. It affects multiple cortical and subcortical neuronal populations. The majority of people with PD develop dementia, which… read more here.
Keywords: body dementia; tau accumulation; accumulation; amyloid tau ... See more keywords
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
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DOI: 10.1038/s41588-021-00785-3
Abstract: The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied… read more here.
Keywords: dementia; body dementia; genetic architecture; genome sequencing ... See more keywords
Validity and reliability of the Turkish version of the ALBA screening instrument for Lewy body dementia in older adults.
Sign Up to like & getrecommendations! Published in 2022 at "Applied neuropsychology. Adult"
DOI: 10.1080/23279095.2022.2142793
Abstract: ALBA screening instrument (ASI) has been demonstrated to be an effective, cheap, and noninvasive clinical instrument to screen for Lewy body dementia (LBD). We aimed to determine the validity and reliability of the Turkish version… read more here.
Keywords: older adults; body dementia; screening instrument; alba screening ... See more keywords
Functional and structural brain network correlates of visual hallucinations in Lewy body dementia
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DOI: 10.1093/brain/awac094
Abstract: Abstract Visual hallucinations are a common feature of Lewy body dementia. Previous studies have shown that visual hallucinations are highly specific in differentiating Lewy body dementia from Alzheimer’s disease dementia and Alzheimer–Lewy body mixed pathology… read more here.
Keywords: visual hallucinations; network; lewy body; body dementia ... See more keywords
Dysfunctional brain dynamics and their origin in Lewy body dementia
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DOI: 10.1093/brain/awz069
Abstract: See Jeganathan and Breakspear (doi:10.1093/brain/awz132) for a scientific commentary on this article. Schumacher et al. report a marked and generalised slowing of whole-brain EEG dynamics in Lewy body dementia that distinguishes it from Alzheimer’s disease… read more here.
Keywords: brain dynamics; dysfunctional brain; body dementia; brain ... See more keywords
Lewy body dementia in an elderly patient with bipolar disorder: Challenges and treatment options.
Sign Up to like & getrecommendations! Published in 2021 at "Bipolar disorders"
DOI: 10.1111/bdi.13079
Abstract: In March 2020, a 62-year-old Iranian woman with bipolar I disorder was referred to the psychiatry outpatient clinic of the Ali Ibn Abi Talib Hospital, Zahedan, Iran, due to a depressive episode with psychotic features… read more here.
Keywords: disorder; dementia elderly; body dementia; bipolar disorder ... See more keywords
Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0787-2
Abstract: The protein α-synuclein (αsyn) forms pathologic aggregates in a number of neurodegenerative diseases including Lewy body dementia (LBD) and Parkinson’s disease (PD). It is unclear why diseases such as LBD may develop widespread αsyn pathology,… read more here.
Keywords: syn; pathology; within amygdala; body dementia ... See more keywords
Progression of Clinical Features in Lewy Body Dementia Can Be Detected Over 6 Months
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DOI: 10.1212/wnl.0000000000012450
Abstract: Objective This study aimed to quantify the trajectory and magnitude of change of the key clinical features and corresponding symptom domains of dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD), including global cognition,… read more here.
Keywords: lewy body; progression clinical; clinical features; body dementia ... See more keywords