Gray Matter Volume Loss in Proposed Brain‐First and Body‐First Parkinson's Disease Subtypes
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DOI: 10.1002/mds.29172
Abstract: α‐Synuclein pathology is associated with neuronal degeneration in Parkinson's disease (PD) and considered to sequentially spread across the brain (Braak stages). According to a new hypothesis of distinct α‐synuclein spreading directions based on the initial… read more here.
Keywords: brain first; parkinson disease; brain; pathology ... See more keywords
Cortical Functional Connectivity Changes in the Body‐First and Brain‐First Subtypes of Parkinson's Disease
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DOI: 10.1002/mds.30071
Abstract: Rapid eye movement (REM) sleep behavior disorder (RBD) may precede motor symptoms in Parkinson's disease (PD) by years. According to a recent hypothesis, premotor RBD (pRBD) is a marker of the PD body‐first subtype, where… read more here.
Keywords: brain first; brain; body first; parkinson disease ... See more keywords
Intermediate polaronic charge transport in organic crystals from a many-body first-principles approach
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DOI: 10.1038/s41524-022-00742-6
Abstract: Charge transport in organic molecular crystals (OMCs) is conventionally categorized into two limiting regimes − band transport, characterized by weak electron-phonon (e-ph) interactions, and charge hopping due to localized polarons formed by strong e-ph interactions. However, between… read more here.
Keywords: transport organic; many body; transport; charge transport ... See more keywords
Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease
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DOI: 10.1186/s13024-025-00866-5
Abstract: Parkinson’s disease (PD) is a highly heterogeneous disorder with distinct phenotypes that can develop well before motor symptoms appear. Recently, two main phenotypes based on the different pathological spreading patterns of PD have been proposed:… read more here.
Keywords: progression; brain first; pathology; body first ... See more keywords
Body-First Subtype of Parkinson’s Disease with Probable REM-Sleep Behavior Disorder Is Associated with Non-Motor Dominant Phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Parkinson's Disease"
DOI: 10.3233/jpd-223511
Abstract: Background: The hypothesis of body-first vs. brain-first subtype of PD has been proposed with REM-Sleep behavior disorder (RBD) defining the former. The body-first PD presumes an involvement of the brainstem in the pathogenic process with… read more here.
Keywords: parkinson disease; first subtype; body first; prbd ... See more keywords