DNMT3B-Mediated Gene Body Methylation Suppresses Aberrant Transcription.
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DOI: 10.1158/2159-8290.cd-rw2017-043
Abstract: DNMT3B methylates intragenic DNA to prevent spurious transcription from cryptic intragenic sites. read more here.
Keywords: transcription; dnmt3b; gene body; mediated gene ... See more keywords
Gene Body Methylation and Transcriptional Activity in ASXL1-Mutant Chronic Myelomonocytic Leukemia
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DOI: 10.1182/blood-2020-134964
Abstract: Introduction: Truncating mutations in Additional Sex Combs-Like 1 (ASXL1) are associated with a high-risk disease phenotype in myeloid malignancies. In chronic myelomonocytic leukemia (CMML), truncating ASXL1 mutations are known to increase transcriptional activity of leukemic… read more here.
Keywords: expression; gene; body methylation; gene body ... See more keywords
Proximal methylation features associated with nonrandom changes in gene body methylation
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DOI: 10.1186/s13059-017-1206-2
Abstract: BackgroundGene body methylation at CG dinucleotides is a widely conserved feature of methylated genomes but remains poorly understood. The Arabidopsis thaliana strain Cvi has depleted gene body methylation relative to the reference strain Col. Here,… read more here.
Keywords: methylation; gene body; body methylation; cgs ... See more keywords
Dnmt1a is essential for gene body methylation and the regulation of the zygotic genome in a wasp
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DOI: 10.1371/journal.pgen.1010181
Abstract: Gene body methylation (GBM) is an ancestral mode of DNA methylation whose role in development has been obscured by the more prominent roles of promoter and CpG island methylation. The wasp Nasonia vitripennis has little… read more here.
Keywords: methylation; gene body; wasp; gene ... See more keywords