BOK displays cell death‐independent tumor suppressor activity in non‐small‐cell lung carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30906
Abstract: As the genomic region containing the Bcl‐2‐related ovarian killer (BOK) locus is frequently deleted in certain human cancers, BOK is hypothesized to have a tumor suppressor function. In the present study, we analyzed primary non‐small‐cell… read more here.
Keywords: tumor suppressor; non small; bok; lung ... See more keywords
Metastability, an emerging concept governing BOK-mediated apoptosis initiation
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25801
Abstract: By regulating mitochondrial outer membrane permeabilization (MOMP), the rate-limiting event in caspase activation, BCL-2 family proteins are responsible for apoptosis initiation [1]. Most BCL-2 proteins obey canonical rules of mitochondrial apoptosis [2]. These rules define… read more here.
Keywords: bok mediated; apoptosis; apoptosis initiation; bcl ... See more keywords
The Multifaceted Roles of the BCL-2 Family Member BOK
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.574338
Abstract: BCL-2–related ovarian killer (BOK) is—despite its identification over 20 years ago—an incompletely understood member of the BCL-2 family. BCL-2 family proteins are best known for their critical role in the regulation of mitochondrial outer membrane… read more here.
Keywords: multifaceted roles; bcl family; family; member ... See more keywords