Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies
Sign Up to like & getrecommendations! Published in 2021 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2021.02.002
Abstract: Homodimeric prodrug-based self-assembled nanoparticles, with carrier-free structure and ultrahigh drug loading, is drawing more and more attentions. Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage. The influence of the linkages on… read more here.
Keywords: prodrug nanoassemblies; diselenide bond; bond containing;
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.2c00084
Abstract: Human African Trypanosomiasis (HAT) is a neglected tropical disease widespread in sub-Saharan Africa. Rhodesain, a cysteine protease of Trypanosoma brucei rhodesiense, has been identified as a valid target for the development of anti-HAT agents. Herein,… read more here.
Keywords: michael acceptors; bond containing; development; urea bond ... See more keywords
Metal-Free Click Modification of Triple Bond-Containing Polyester with Azide-Functionalized Vegetable Oil: Plasticization and Tunable Solvent Adsorption
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DOI: 10.1021/acsomega.2c01525
Abstract: Pressure from environmental nongovernmental organizations and the public has accelerated research on the development of innovative and renewable polymers and additives. Recently, biobased “green” plasticizers that can be covalently attached to replace toxic and migratory… read more here.
Keywords: plasticization; bond containing; oil; containing polyester ... See more keywords
The length of disulfide bond-containing linkages impacts the oral absorption and antitumor activity of paclitaxel prodrug-loaded nanoemulsions.
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DOI: 10.1039/d1nr01359a
Abstract: The rational design of oral paclitaxel (PTX) preparations is still a challenge. Many studies focus on developing PTX-loaded nanoemulsions (NEs) for oral administration. Unfortunately, PTX has poor affinity with the commonly used oil phases, leading… read more here.
Keywords: disulfide bond; ptx; containing linkages; bond containing ... See more keywords
Raman inks based on triple-bond-containing polymeric nanoparticles for security.
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DOI: 10.1039/d2nr00788f
Abstract: Developing security inks with spectral outputs/multiple colors, which have unique identification characteristics, is of great importance in enhancing the anti-counterfeiting strength of ink anti-counterfeiting technology. Herein, a print-driven triple-bond coding mode is proposed for the… read more here.
Keywords: bond containing; security; anti counterfeiting; containing polymeric ... See more keywords