Exploring Guanidinium Organocatalysts for Hypoiodite-Mediated Reactions.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical record"
DOI: 10.1002/tcr.202300030
Abstract: This account describes our recent work on developing guanidinium hypoiodite- catalysts for oxidative carbon-nitrogen and carbon-carbon bond-forming reactions. These reactions proceeded smoothly using guanidinium hypoiodite generated in situ by treating 1,3,4,6,7-hexahydro-2H-pyrimido[1,2-a]pyrimidine hydroiodide salts with an oxidant.… read more here.
Keywords: carbon; guanidinium organocatalysts; organocatalysts hypoiodite; exploring guanidinium ... See more keywords
High-performance miniature CSTR for biphasic C–C bond-forming reactions
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2017.10.114
Abstract: Chemical transformations used in fine chemical manufacturing often involve two-phase interaction for which mass transfer limitations can lead to prolonged reaction time and reduced productivity. We present a high-performance miniature continuous stirred-tank reactor (CSTR), with… read more here.
Keywords: cstr; performance miniature; forming reactions; biphasic bond ... See more keywords
Exploring the influence of designer surfactant hydrophobicity in key C C/C N bond forming reactions
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2019.01.006
Abstract: Abstract Designer micellar medium was explored for the transformation of diverse anilines to the corresponding densely substituted biologically relevant skatole derivatives in an aqueous medium via 5-exo-trig cyclization reaction. The scope of the reaction was… read more here.
Keywords: designer; bond forming; hydrophobicity; exploring influence ... See more keywords
Guanidine organocatalysis for enantioselective carbon-heteroatom bond-forming reactions
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.12.058
Abstract: Abstract Guanidine-containing molecules have been employed as organocatalysts, and chiral guanidines have been widely explored as catalysts for mediating asymmetric reactions by constructing an asymmetric reaction environment. Currently, many guanidine-catalyzed asymmetric reactions are available, and… read more here.
Keywords: carbon heteroatom; guanidine organocatalysis; heteroatom bond; organocatalysis enantioselective ... See more keywords
Selective C-O Bond Forming Reactions at Indole-C2-Position toward Polycyclic Indolone or Indolinone Derivatives Tethered with Medium-Sized Rings.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02398
Abstract: A methodology involving the chemoselective synthesis of tetracyclic [1,3]oxazino[3,2-a]indol-4-one or tetracyclic [1,3]oxazino[3,2-a]indoline-4-one tethered with a medium-sized ring by cross dehydrogenative coupling (CDC) or nucleophilic addition (NA) reaction has been developed. [1,3]Oxazino[3,2-a]indol-4-one compounds fused with a… read more here.
Keywords: tethered medium; medium sized; sized ring; medium ... See more keywords
One-Step Synthesis of Benzophosphole Derivatives from Arylalkynes by Phosphenium-Dication-Mediated Sequential C-P/C-C Bond Forming Reaction.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00263
Abstract: A metal-free, phosphenium-dication-mediated sequential C-P and C-C bond forming reaction has been developed. This protocol can provide concise access to the (di)benzophosphole derivatives in one synthetic operation from the readily available and simple arylalkynes and… read more here.
Keywords: mediated sequential; phosphenium dication; reaction; sequential bond ... See more keywords
Synthesis of 1,1-Disubstituted Indenes and Dihydronaphthalenes through C-C/C-C Bond-Forming Pd-Catalyzed Autotandem Reactions.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01870
Abstract: A novel synthesis of 1,1-disubstituted 1H-indenes is described involving the Pd-catalyzed cascade reaction between o-bromophenyl-β-bromostyrenes and N-tosylhydrazones in a process comprising the consecutive formation of two Csp3-C bonds on the same carbon atom: the cross-coupling… read more here.
Keywords: indenes dihydronaphthalenes; dihydronaphthalenes bond; synthesis disubstituted; bond forming ... See more keywords
Development of a One-Pot Four C-C Bond-Forming Sequence Based on Palladium/Ruthenium Tandem Catalysis.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03556
Abstract: A one-pot four C-C bond-forming sequence has been developed using two distinct transition metal complexes. The sequence entails a double Pd-catalyzed allylic alkylation followed by a Ru-catalyzed ring-closing metathesis and a Pd-catalyzed Heck coupling. The… read more here.
Keywords: bond; four bond; pot four; one pot ... See more keywords
Palladium-Catalyzed [3 + 2]-C-C/N-C Bond-Forming Annulation.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01616
Abstract: The synthesis of bi- and tricyclic structures incorporating pyrrolidone rings is disclosed, starting from resonance-stabilized acetamides and cyclic α,β-unsaturated-γ-oxycarbonyl derivatives. This process involves an intermolecular Tsuji-Trost allylation/intramolecular nitrogen 1,4-addition sequence. Crucial for the success of… read more here.
Keywords: annulation; palladium catalyzed; catalyzed bond; forming annulation ... See more keywords
Efficient chemoenzymatic synthesis of α-aryl aldehydes as intermediates in C-C bond forming biocatalytic cascades.
Sign Up to like & getrecommendations! Published in 2022 at "ACS catalysis"
DOI: 10.1021/acscatal.2c02369
Abstract: Multi-enzyme biocatalytic cascades are emerging as practical routes for the synthesis of complex bioactive molecules. However, the relative sparsity of water-stable carbon electrophiles limits the synthetic complexity of molecules made from such cascades. Here, we… read more here.
Keywords: biocatalytic cascades; aryl aldehydes; bond forming; synthesis ... See more keywords
Versatile Chemo-Biocatalytic Cascade Driven by a Thermophilic and Irreversible C–C Bond-Forming α-Oxoamine Synthase
Sign Up to like & getrecommendations! Published in 2023 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.3c00243
Abstract: We report a chemo-biocatalytic cascade for the synthesis of substituted pyrroles, driven by the action of an irreversible, thermostable, pyridoxal 5′-phosphate (PLP)-dependent, C–C bond-forming biocatalyst (ThAOS). The ThAOS catalyzes the Claisen-like condensation between various amino… read more here.
Keywords: chemo biocatalytic; versatile chemo; biocatalytic cascade; bond forming ... See more keywords