Impact of depth filtration on disulfide bond reduction during downstream processing of monoclonal antibodies from CHO cell cultures
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DOI: 10.1002/bit.26964
Abstract: Monoclonal antibody interchain disulfide bond reduction was observed in a Chinese Hamster Ovary manufacturing process that used single‐use technologies. A similar reduction has been reported for processes that involved high mechanical shear recovery unit operations,… read more here.
Keywords: reduction; disulfide bond; depth filtration; bond reduction ... See more keywords
Nickel-catalysed C O bond reduction of 2,4,6-triaryloxy-1,3,5-triazines in 2-methyltetrahydrofuran
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DOI: 10.1016/j.cclet.2018.09.009
Abstract: Abstract A nickel-catalysed reduction of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine (TCT) in ecofriendly 2-methyltetrahydrofuran (2-MeTHF) is described. The phenol-TCT derivatives were readily prepared using grinding method in short time without further purification. This catalytic system… read more here.
Keywords: bond reduction; reduction; nickel catalysed; phenol tct ... See more keywords