Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction
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DOI: 10.7554/elife.66181
Abstract: Clamp loaders are AAA+ ATPases that load sliding clamps onto DNA. We mapped the mutational sensitivity of the T4 bacteriophage sliding clamp and clamp loader by deep mutagenesis, and found that residues not involved in… read more here.
Keywords: bonded junction; clamp loaders; clamp; hydrogen bonded ... See more keywords