Construction of C(sp2)-Si Bonds via Ligand-Promoted C-C Bonds Cleavage of Unstrained Ketones.
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DOI: 10.1021/acs.orglett.2c02841
Abstract: Herein, we report an efficient palladium-catalyzed silylation of aryl and alkenyl ketones via C-C bond cleavage and C-Si bond formation. This protocol features high efficiency and broad substrate scope. Further applications in the late-stage diversification… read more here.
Keywords: via ligand; cleavage; ligand promoted; bonds via ... See more keywords
Azolation of Benzylic C-H Bonds via Photoredox-Catalyzed Carbocation Generation.
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DOI: 10.1021/jacs.2c12850
Abstract: A visible-light photoredox-catalyzed method is reported that enables the coupling between benzylic C-H substrates and N-H azoles. Classically, medicinally relevant N-benzyl azoles are produced via harsh substitution conditions between the azole and a benzyl electrophile… read more here.
Keywords: azolation benzylic; benzylic bonds; via photoredox; bonds via ... See more keywords
Site-selective functionalization of remote aliphatic C–H bonds via C–H metallation
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DOI: 10.1039/d0sc05944g
Abstract: Directing group assistance provided a paradigm for controlling site-selectivity in transition metal-catalyzed C–H functionalization reactions. However, the kinetically and thermodynamically favored formation of 5-membered metallacycles has greatly hampered the selective activation of remote C(sp3)–H bonds… read more here.
Keywords: via metallation; selective functionalization; functionalization remote; bonds via ... See more keywords