Bone adaptation: safety factors and load predictability in shaping skeletal form.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.115114
Abstract: John Currey published extensively on skeletal adaptation in relation to the mechanical functions that bones serve, specifically how bone adapts to mechanical loading during an individual's lifetime as well as over evolutionary time. Although controlled… read more here.
Keywords: bone adaptation; bone; load predictability; adaptation ... See more keywords
Variation in bone response to the placement of percutaneous osseointegrated endoprostheses: A 24-month follow-up in sheep
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DOI: 10.1371/journal.pone.0221850
Abstract: Percutaneous osseointegrated (OI) devices for amputees are metallic endoprostheses, that are surgically implanted into the residual stump bone and protrude through the skin, allowing attachment of an exoprosthetic limb. In contrast to standard socket suspension… read more here.
Keywords: percutaneous device; bone adaptation; percutaneous osseointegrated; bone ... See more keywords
Manipulating load-induced fluid flow in vivo to promote bone adaptation.
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DOI: 10.2139/ssrn.4168547
Abstract: Mechanical stimulation is critical to maintaining bone mass and strength. Strain has been commonly thought of as the mechanical stimulus driving bone adaptation. However, numerous studies have hypothesized that fluid flow in the lacunar-canalicular system… read more here.
Keywords: bone; fluid flow; bone adaptation;
Differential bone adaptation to mechanical unloading and reloading in young, old, and osteocyte deficient mice.
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DOI: 10.2139/ssrn.4254484
Abstract: Mechanical unloading causes rapid loss of bone structure and strength, which gradually recovers after resuming normal loading. However, it is not well established how this adaptation to unloading and reloading changes with age. Clinically, elderly… read more here.
Keywords: bone; cortical bone; unloading reloading; mice ... See more keywords
Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1140673
Abstract: Mechanical loading is a key factor governing bone adaptation. Both preclinical and clinical studies have demonstrated its effects on bone tissue, which were also notably predicted in the mechanostat theory. Indeed, existing methods to quantify… read more here.
Keywords: loading frequency; micro; time lapsed; bone adaptation ... See more keywords