USP48 alleviates bone cancer pain and regulates MrgC stabilization in spinal cord neurons of male mice.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of pain"
DOI: 10.1002/ejp.2102
Abstract: BACKGROUND Ubiquitin-mediated degradation of the Mas-related G protein-coupled receptor C (MrgC) reduces the number of receptors. However, the specific deubiquitinating enzyme to antagonize this process has not been reported. In this study, we investigated the… read more here.
Keywords: mrgc; cancer pain; bone cancer;
Morin Suppresses Astrocyte Activation and Regulates Cytokine Release in Bone Cancer Pain Rat Models
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DOI: 10.1002/ptr.5849
Abstract: As inflammatory and immune responses are involved in pathophysiology of debilitating neuropathic pain, reagents that can modulate these two responses may have therapeutic potential. Morin, derived from the moraceae family of plants, benefits inflammation‐related diseases,… read more here.
Keywords: bone cancer; cancer pain; activation; cancer ... See more keywords
Combined application of diclofenac and celecoxib with an opioid yields superior efficacy in metastatic bone cancer pain: a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-017-1133-y
Abstract: AbstractBackgroundMetastatic bone cancer pain is one of the most common clinical cancer pains and is caused by many factors. This study was conducted to explore the clinical efficacy of using two non-steroidal anti-inflammatory drugs (NSAIDs)… read more here.
Keywords: bone cancer; metastatic bone; cancer pain; using two ... See more keywords
Tissue-engineered 3D Models for Elucidating Primary and Metastatic Bone Cancer Progression.
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DOI: 10.1016/j.actbio.2019.08.020
Abstract: Malignant bone tumors are aggressive neoplasms which arise from bone tissue or as a result of metastasis. The most prevalent types of cancer, such as breast, prostate, and lung cancer, all preferentially metastasize to bone,… read more here.
Keywords: bone cancer; tissue; bone; cancer progression ... See more keywords
Metformin and primary bone cancer risk in Taiwanese patients with type 2 diabetes mellitus.
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DOI: 10.1016/j.bone.2021.116037
Abstract: BACKGROUND The effect of metformin on primary bone cancer risk has not been researched. This retrospective cohort study investigated the risk of primary bone cancer between metformin initiators and non-metformin initiators in patients with type… read more here.
Keywords: risk; primary bone; metformin initiators; bone cancer ... See more keywords
Multifunctional mesoporous magnetic Mg2SiO4–CuFe2O4 core-shell nanocomposite for simultaneous bone cancer therapy and regeneration
Sign Up to like & getrecommendations! Published in 2019 at "Ceramics International"
DOI: 10.1016/j.ceramint.2019.06.205
Abstract: Abstract Traditional bone grafts have shown their abilities for successful bone regeneration, but they are not able to address other critical problems such as infection and bone cancer beside bone regeneration. Multifunctional nanocomposites are highly… read more here.
Keywords: bone cancer; regeneration; bone; mg2sio4 cufe2o4 ... See more keywords
Suppression of the acute upregulation of phosphorylated-extracellular regulated kinase in ventral tegmental area by a μ-opioid receptor agonist is related to resistance to rewarding effects in a mouse model of bone cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2016.11.004
Abstract: We investigated the mechanisms underlying the suppression of the rewarding effects of opioids using the femur bone cancer (FBC) mouse model. The rewarding and antinociceptive effects of subcutaneously administered morphine and oxycodone in the FBC… read more here.
Keywords: suppression; bone cancer; rewarding effects; morphine ... See more keywords
Maternally expressed, paternally imprinted, embryonic non-coding RNA are expressed in osteosarcoma, Ewing sarcoma and spindle cell sarcoma.
Sign Up to like & getrecommendations! Published in 2019 at "Pathology"
DOI: 10.1016/j.pathol.2018.08.014
Abstract: In a human embryo it takes 8 weeks after fertilisation for the skeleton to begin to form, one of the last organs to develop before becoming a foetus. Mesenchymal progenitors, derived from neural crest cells,… read more here.
Keywords: osteosarcoma ewing; bone cancer; bone; ewing sarcoma ... See more keywords
circStrn3 is involved in bone cancer pain regulation in a rat model
Sign Up to like & getrecommendations! Published in 2020 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmaa018
Abstract: Abstract Bone cancer pain (BCP) is a common chronic pain that is caused by a primary or metastatic bone tumor. More detailed molecular mechanisms of BCP are warranted. In this study, we established a BCP… read more here.
Keywords: bone cancer; cancer pain; circstrn3; bone ... See more keywords
Decitabine attenuates nociceptive behavior in a murine model of bone cancer pain
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DOI: 10.1097/j.pain.0000000000001442
Abstract: Abstract Bone cancer metastasis is extremely painful and decreases the quality of life of the affected patients. Available pharmacological treatments are not able to sufficiently ameliorate the pain, and as patients with cancer are living… read more here.
Keywords: bone cancer; cancer pain; decitabine; cancer ... See more keywords
Upregulation of LncRNA71132 in spinal cord regulates hypersensitivity in rat model of bone cancer pain.
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DOI: 10.1097/j.pain.0000000000002678
Abstract: ABSTRACT Bone cancer pain (BCP) is a pervasive clinical symptom which impairs the quality life. Long non-coding RNAs (lncRNAs) are enriched in the central nervous system (CNS) and play indispensable roles in numerous biological processes,… read more here.
Keywords: cancer pain; bone cancer; mir 143; expression ... See more keywords