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   Articles with "bone defects" as a keyword



Multi‐Core Functional Microspheres for Osteoporotic Bone Defects Therapy: From Local Treatment to Systematic Relief

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recommendations! Published in 2025 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202500115

Abstract: Bone repair in patients with osteoporosis is a major challenge. In this study, multi‐enhanced bioactive microsphere scaffolds (abbr. GMA MSs) composed of a gelatin framework with alendronate (ALN) and magnesium (Mg) spheres encapsulants are developed… read more here.

Keywords: treatment; gma mss; osteoporotic bone; bone ... See more keywords

Bioelectrically Reprogramming Hydrogels Rejuvenate Vascularized Bone Regeneration in Senescence

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recommendations! Published in 2025 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202403837

Abstract: Senescent bone tissue displays a pathological imbalance characterized by decreased angiogenesis, disrupted bioelectric signaling, ion dysregulation, and reduced stem cell differentiation. Once bone defects occur, this pathological imbalance makes them difficult to repair. An innovative… read more here.

Keywords: hydrogel; vascularized bone; bone regeneration; bone ... See more keywords

The Treatment of Large Bone Defects with Atrophic Nonunion by Bioactive Scaffolds Remodeling the Regeneration Microenvironment

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recommendations! Published in 2025 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202500120

Abstract: Atrophic nonunion, a particularly challenging complication of diaphyseal bone fractures, arises from a deteriorated regenerative microenvironment characterized by insufficient vascularization and pathological accumulation of reactive oxygen species (ROS). To address this clinical challenge, a dual‐function… read more here.

Keywords: bioactive scaffolds; atrophic nonunion; microenvironment; bone ... See more keywords

Temporal Immunomodulatory Hydrogel Regulating the Immune-Osteogenic Cascade for Infected Bone Defects Regeneration.

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recommendations! Published in 2025 at "Advanced materials"

DOI: 10.1002/adma.202514419

Abstract: Early pathogen clearance and immunomodulation are critical for the restoration of infected bone defects. Conventional osteoimmunomodulatory strategies mainly emphasize M2 macrophage‐mediated bone regeneration, neglecting the pivotal role of early‐stage M1 macrophage‐activated immune response in microbial… read more here.

Keywords: temporal immunomodulatory; infected bone; immunomodulatory hydrogel; bone ... See more keywords

Targeting Bacteria‐Induced Ferroptosis of Bone Marrow Mesenchymal Stem Cells to Promote the Repair of Infected Bone Defects

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202404453

Abstract: The specific mechanisms underlying bacteria‐triggered cell death and osteogenic dysfunction in host bone marrow mesenchymal stem cells (BMSCs) remain unclear, posing a significant challenge to the repair of infected bone defects. This study identifies ferroptosis… read more here.

Keywords: bone marrow; repair; ferroptosis; infected bone ... See more keywords

Quercetin‐Loaded Bioglass Injectable Hydrogel Promotes m6A Alteration of Per1 to Alleviate Oxidative Stress for Periodontal Bone Defects (Adv. Sci. 29/2024)

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202470170

Abstract: Periodontal Therapy with Quercetin Quercetin‐loaded injectable hydrogels can effectively alleviate the oxidative stress microenvironment and promote bone defect repair by modulating the m6A modification of Per1 in orofacial mesenchymal stem cells. This hydrogel system has… read more here.

Keywords: alleviate oxidative; quercetin; oxidative stress; quercetin loaded ... See more keywords

Vitamins K2 and D3 enhance guided bone regeneration in rat calvarial bone defects.

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recommendations! Published in 2025 at "Journal of periodontology"

DOI: 10.1002/jper.11372

Abstract: BACKGROUND Vitamins K2 and D3 exhibit anabolic effects on bone metabolism, but their effectiveness in guided bone regeneration (GBR) is unclear. The present study aimed to investigate the impacts of vitamins K2 and D3 administration… read more here.

Keywords: vitamin; bone regeneration; bone; guided bone ... See more keywords

Recent Advances in Synthetic and Natural Biomaterials-Based Therapy for Bone Defects.

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recommendations! Published in 2022 at "Macromolecular bioscience"

DOI: 10.1002/mabi.202100383

Abstract: Synthetic and natural biomaterials are a promising alternative for the treatment of critical-sized bone defects. Several parameters such as their porosity, surface, and mechanical properties are extensively pointed out as key points to recapitulate the… read more here.

Keywords: synthetic natural; based therapy; natural biomaterials; bone ... See more keywords

PLGA Cage-like Structures Loaded with Sr/Mg-doped Hydroxyapatite for Repairing Osteoporotic Bone Defects.

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recommendations! Published in 2022 at "Macromolecular bioscience"

DOI: 10.1002/mabi.202200092

Abstract: Poly (lactic-co-glycolic acid) (PLGA)-based porous structures have a widespread application in bone defects. To solve its flaws in the bone application, hydroxyapatite (HA) is often introduced into PLGA-based systems, and ion doping endows HA with… read more here.

Keywords: plga cage; cage like; bone; repairing osteoporotic ... See more keywords

Total flavonoids of Rhizoma drynariae promote angiogenesis and osteogenesis in bone defects

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recommendations! Published in 2022 at "Phytotherapy Research"

DOI: 10.1002/ptr.7525

Abstract: Bone defects are difficult to heal, which conveys a heavy burden to patients' lives and their economy. The total flavonoids of Rhizoma drynariae (TFRD) can promote the osteogenesis of distraction osteogenesis. However, the dose effect… read more here.

Keywords: flavonoids rhizoma; bone; rhizoma drynariae; osteogenesis ... See more keywords

Functionalized Metal-Organic Framework-Modified Hydrogel That Breaks the Vicious Cycle of Inflammation and ROS for Repairing of Diabetic Bone Defects.

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recommendations! Published in 2023 at "Small"

DOI: 10.1002/smll.202206919

Abstract: The regeneration of diabetic bone defects remains challenging. Hyperglycemia causes inflammation state and excessive reactive oxygen species (ROS) during bone regeneration period. These two effects reinforce one another and create an endless loop that is… read more here.

Keywords: vicious cycle; inflammation; diabetic bone; bone defects ... See more keywords