High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR4.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.120
Abstract: Bone destruction of maxillary and mandibular bone by invasive oral squamous cell cancer (OSCC) raises various problems in the management of patients, resulting in poor outcomes and survival. However, the mechanism behind bone destruction by… read more here.
Keywords: high mobility; oral squamous; destruction; mobility group ... See more keywords
Targeting TSP-1 decreased periodontitis by attenuating extracellular matrix degradation and alveolar bone destruction.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107618
Abstract: An important factor in periodontitis pathogenesis relates to a network of interactions of various cytokines. Thrombospondin-1 (TSP-1) is upregulated in several inflammatory diseases. We previously found that Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS)-induced TSP-1 production,… read more here.
Keywords: extracellular matrix; alveolar bone; bone destruction; periodontitis ... See more keywords
Tuning Ligand Density to Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction.
Sign Up to like & getrecommendations! Published in 2020 at "ACS nano"
DOI: 10.1021/acsnano.9b04571
Abstract: Breast cancer patients are at high risk for bone metastasis. Metastatic bone disease is a major clinical problem that leads to a reduction in mobility, increased risk of pathologic fracture, severe bone pain, and other… read more here.
Keywords: tumor; gant58; btnps; bone ... See more keywords
NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2017.115
Abstract: NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma read more here.
Keywords: osteoclast differentiation; differentiation bone; induces osteoclast; nek2 induces ... See more keywords
Glutathione accelerates osteoclast differentiation and inflammatory bone destruction
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Research"
DOI: 10.1080/10715762.2018.1563782
Abstract: Abstract Chronic inflammation associated with bone tissues often destructs bones, which is essentially performed by osteoclasts in the presence of immunoregulatory molecules. Hence, regulating osteoclastogenesis is crucial to develop therapeutics for bone-destructive inflammatory diseases. It… read more here.
Keywords: inflammatory bone; bone; osteoclast differentiation; bone destruction ... See more keywords
Akkermansia muciniphila reduces Porphyromonas gingivalis-induced inflammation and periodontal bone destruction.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of clinical periodontology"
DOI: 10.1111/jcpe.13214
Abstract: AIM Akkermansia muciniphila is a beneficial gut commensal, whose anti-inflammatory properties have recently been demonstrated. This study aimed to evaluate the effect of A.muciniphila on Porphyromonas gingivalis elicited inflammation. MATERIAL AND METHODS In lean and… read more here.
Keywords: akkermansia muciniphila; inflammation; bone; muciniphila ... See more keywords
FRI0024 MICRORNA-146A controls local bone destruction by regulating fibroblast induced osteoclastogenesis in inflammatory arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.3384
Abstract: Background MicroRNA (MiR-) 146a plays an important role in the regulation of the innate immune response and has also been shown to suppress cancer development in myeloid cells. Although in late stages of arthritis elevated… read more here.
Keywords: mir 146a; htnftg mice; role; arthritis ... See more keywords
Decreased Expression of Semaphorin3A/Neuropilin-1 Signaling Axis in Apical Periodontitis
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/8724503
Abstract: Apical periodontitis (AP) is a chronic infection of endodontic origin accompanied with bone destruction around the apical region. Semaphorin3A (Sema3A) and neuropilin-1 (Nrp1) are regarded as a pair of immune regulators in bone metabolism. In… read more here.
Keywords: apical periodontitis; expression; sema3a nrp1; bone destruction ... See more keywords
Comprehensive Treatment of Severe Periodontal and Periimplant Bone Destruction Caused by Iatrogenic Factors
Sign Up to like & getrecommendations! Published in 2018 at "Case Reports in Dentistry"
DOI: 10.1155/2018/7174608
Abstract: Dental implant success requires placement after periodontal therapy, with adequate bone volume, plaque control, primary stability, control of risk factors, and use of well-designed prostheses. This report describes the surgical and prosthetic management of a… read more here.
Keywords: destruction; periimplant bone; bone; periodontal periimplant ... See more keywords
HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.128713
Abstract: Osteolytic bone lesions and hypercalcemia are common, serious complications in adult T cell leukemia/lymphoma (ATL), an aggressive T cell malignancy associated with human T cell leukemia virus type 1 (HTLV-1) infection. The HTLV-1 viral oncogene… read more here.
Keywords: bone; hbz; cell leukemia; bone destruction ... See more keywords
The roles of osteocytes in alveolar bone destruction in periodontitis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-020-02664-7
Abstract: Periodontitis, a bacterium-induced inflammatory disease that is characterized by alveolar bone loss, is highly prevalent worldwide. Elucidating the underlying mechanisms of alveolar bone loss in periodontitis is crucial for understanding its pathogenesis. Classically, bone cells,… read more here.
Keywords: bone; alveolar bone; bone loss; periodontitis ... See more keywords