Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption
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DOI: 10.1002/2211-5463.12258
Abstract: Abnormalities of bone turnover are commonly observed in patients with chronic kidney disease (CKD), and the low‐turnover bone disease is considered to be associated with low serum parathyroid hormone (PTH) levels and skeletal resistance to… read more here.
Keywords: bone formation; turnover; bone resorption; disease ... See more keywords
Growth‐Factor Free Multicomponent Nanocomposite Hydrogels That Stimulate Bone Formation
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DOI: 10.1002/adfm.201906205
Abstract: Synthetic osteo‐promoting materials that are able to stimulate and accelerate bone formation without the addition of exogenous cells or growth factors represent a major opportunity for an aging world population. A co‐assembling system that integrates… read more here.
Keywords: growth factor; bone formation; multicomponent; formation ... See more keywords
Hypoxia Drives Material‐Induced Heterotopic Bone Formation by Enhancing Osteoclastogenesis via M2/Lipid‐Loaded Macrophage Axis
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DOI: 10.1002/advs.202207224
Abstract: Heterotopic ossification (HO) is a double‐edged sword. Pathological HO presents as an undesired clinical complication, whereas controlled heterotopic bone formation by synthetic osteoinductive materials shows promising therapeutic potentials for bone regeneration. However, the mechanism of… read more here.
Keywords: bone formation; heterotopic bone; material induced; hypoxia ... See more keywords
SIRT1/Notch1 signal axis involves in the promoting effect of Segetalin B on bone formation
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DOI: 10.1002/ddr.22001
Abstract: Phytoestrogens are a class of potential natural medicines for treating postmenopausal osteoporosis (PMOP). Segetalin B (SB) is a cyclic peptide compound showing estrogenic activity. This study reports the effect of SB on bone formation among… read more here.
Keywords: bone formation; ovx rats; effect; bone ... See more keywords
Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts
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DOI: 10.1002/jbmr.3175
Abstract: Bone formation is coupled to bone resorption throughout life. However, the coupling mechanisms are not fully elucidated. Using Tnfrsf11b‐deficient (OPG–/–) mice, in which bone formation is clearly coupled to bone resorption, we found here that… read more here.
Keywords: sclerostin expression; bone formation; bone; expression ... See more keywords
Overexpression of MiR‐335‐5p Promotes Bone Formation and Regeneration in Mice
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DOI: 10.1002/jbmr.3230
Abstract: MicroRNAs (miRNAs) and the Wnt signaling pathway play critical roles in regulating bone development and homeostasis. Our previous study revealed high expression of miR‐335‐5p in osteoblasts and hypertrophic chondrocytes in mouse embryos and the ability… read more here.
Keywords: bone; mir 335; transgenic mice; bone formation ... See more keywords
Discoidin Receptor 2 Controls Bone Formation and Marrow Adipogenesis
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DOI: 10.1002/jbmr.3534
Abstract: The authors notified the editors of JBMR about a possible duplication (in reverse orientation) of the T-ERK panel from Fig. 1A in an article in the Journal of Biological Chemistry (1) and in Fig. 5B… read more here.
Keywords: formation marrow; receptor controls; controls bone; discoidin receptor ... See more keywords
A Novel Rhein Derivative Modulates Bone Formation and Resorption and Ameliorates Estrogen‐Dependent Bone Loss
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3604
Abstract: Osteoporosis, an osteolytic disease that affects millions of people worldwide, features a bone remodeling imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Identifying dual target‐directed agents that inhibit excessive bone resorption and… read more here.
Keywords: bone; bone formation; bone loss; resorption ... See more keywords
VEGFA From Early Osteoblast Lineage Cells (Osterix+) Is Required in Mice for Fracture Healing
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DOI: 10.1002/jbmr.3755
Abstract: Bone formation via intramembranous and endochondral ossification is necessary for successful healing after a wide range of bone injuries. The pleiotropic cytokine, vascular endothelial growth factor A (VEGFA) has been shown, via nonspecific pharmacologic inhibition,… read more here.
Keywords: angiogenesis; fracture; bone formation; bone ... See more keywords
Early Effects of Abaloparatide on Bone Formation and Resorption Indices in Postmenopausal Women With Osteoporosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4243
Abstract: Anabolic osteoporosis drugs improve bone mineral density by increasing bone formation. The objective of this study was to evaluate the early effects of abaloparatide on indices of bone formation and to assess the effect of… read more here.
Keywords: bone formation; cancellous endocortical; formation; bone ... See more keywords
miR‐433‐3p suppresses bone formation and mRNAs critical for osteoblast function in mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4339
Abstract: MicroRNAs (miRNAs) are key posttranscriptional regulators of osteoblastic commitment and differentiation. miR‐433‐3p was previously shown to target Runt‐related transcription factor 2 (Runx2) and to be repressed by bone morphogenetic protein (BMP) signaling. Here, we show… read more here.
Keywords: bone; mir 433; differentiation; bone formation ... See more keywords