The role of Meteorin‐like in skeletal development and bone fracture healing
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.25286
Abstract: Meteorin‐like protein (Metrnl), homologous to the initially identified neurotrophic factor Meteorin, is a secreted, multifunctional protein. Here we used mouse models to investigate Metrnl's role in skeletal development and bone fracture healing. During development Metrnl… read more here.
Keywords: bone; development; bone fracture; fracture healing ... See more keywords
Electrical stimulation-based bone fracture treatment, if it works so well why do not more surgeons use it?
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Trauma and Emergency Surgery"
DOI: 10.1007/s00068-019-01127-z
Abstract: Background Electrical stimulation (EStim) has been proven to promote bone healing in experimental settings and has been used clinically for many years and yet it has not become a mainstream clinical treatment. Methods To better… read more here.
Keywords: bone fracture; fracture; surgeons use; treatment ... See more keywords
Stress analysis in a bone fracture fixed with topology-optimised plates
Sign Up to like & getrecommendations! Published in 2019 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-019-01240-3
Abstract: The design of commercially available fixation plates and the materials used for their fabrication lead to the plates being stiffer than bone. Consequently, commercial plates are prone to induce bone stress shielding. In this study,… read more here.
Keywords: stress shielding; bone fracture; bone; topology ... See more keywords
Role of Dynamic Loading on Early Stage of Bone Fracture Healing
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-018-2083-x
Abstract: After fracture, mesenchymal stem cells (MSCs) and growth factors migrate into the fracture callus to exert their biological actions. Previous studies have indicated that dynamic loading induced tissue deformation and interstitial fluid flow could produce… read more here.
Keywords: dynamic loading; bone fracture; fracture; stage bone ... See more keywords
Hypoxic mesenchymal stem cell-derived exosomes promote bone fracture healing by the transfer of miR-126.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.12.020
Abstract: Increasing evidence has suggested that paracrine mechanisms might be involved in the underlying mechanism of mesenchymal stem cells (MSCs) transplantation, and exosomes are an important component of this paracrine role. However, MSCs are usually exposed… read more here.
Keywords: hypo exos; bone fracture; mir 126; fracture ... See more keywords
Association of normalized protein catabolic rate (nPCR) with the risk of bone fracture in patients undergoing maintenance hemodialysis: The Q-Cohort Study.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2020.07.003
Abstract: BACKGROUND & AIMS Normalized protein catabolic rate (nPCR) is used as a surrogate for daily dietary protein intake and nutritional status in patients receiving maintenance hemodialysis. It remains uncertain whether the nPCR level is associated… read more here.
Keywords: hemodialysis; risk bone; bone fracture; fracture ... See more keywords
Causal effects of homocysteine levels on the changes of bone mineral density and risk for bone fracture: A two-sample mendelian randomization study.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2021.02.045
Abstract: BACKGROUND & AIMS Observational studies have demonstrated the relations of homocysteine (HCY) with bone mineral density (BMD) and bone fracture risk, but yielding contradictory results. The present study was conducted to evaluate whether the genetically… read more here.
Keywords: hcy; risk; bone fracture; bmd ... See more keywords
Identification of fracture zones and its application in automatic bone fracture reduction
Sign Up to like & getrecommendations! Published in 2017 at "Computer methods and programs in biomedicine"
DOI: 10.1016/j.cmpb.2016.12.014
Abstract: BACKGROUND AND OBJECTIVE The preoperative planning of bone fractures using information from CT scans increases the probability of obtaining satisfactory results, since specialists are provided with additional information before surgery. The reduction of complex bone… read more here.
Keywords: reduction; bone fracture; fracture; fracture zones ... See more keywords
Systemic leptin administration alters callus VEGF levels and enhances bone fracture healing in wildtype and ob/ob mice.
Sign Up to like & getrecommendations! Published in 2018 at "Injury"
DOI: 10.1016/j.injury.2018.06.040
Abstract: INTRODUCTION Leptin's role in bone formation has been reported, however, its mechanism of affecting bone metabolism is remaining unclear. In this study, we aimed to test whether leptin has a positive effect on fracture healing… read more here.
Keywords: vegf levels; bone fracture; fracture; callus vegf ... See more keywords
Bone fracture healing is delayed in splenectomic rats
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2016.12.005
Abstract: Aims: Splenectomy is sometimes required in bone fracture patients. The present study aims to investigate the effect of splenectomy on fracture healing in rats. Main methods: Rats underwent osteotomy were subjected to splenectomy. The effects… read more here.
Keywords: fracture site; bone fracture; fracture; expression ... See more keywords
Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01493
Abstract: Current therapies of steroid hormone-dependent diseases predominantly alter steroid hormone concentrations (or their actions) in plasma, in target and nontarget tissues alike, rather than in target organs only. Targeted therapy through the inhibition of steroidogenic… read more here.
Keywords: dehydrogenase type; bone fracture; therapy; hydroxysteroid dehydrogenase ... See more keywords