The RhoGAP Myo9b Promotes Bone Growth by Mediating Osteoblastic Responsiveness to IGF‐1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3192
Abstract: The Ras homolog A (RhoA) subfamily of Rho guanosine triphosphatases (GTPases) regulates actin‐based cellular functions in bone such as differentiation, migration, and mechanotransduction. Polymorphisms or genetic ablation of RHOA and some of its regulatory guanine… read more here.
Keywords: bone growth; bone; igf; myo9b ... See more keywords
Glucocorticoids Decrease Longitudinal Bone Growth in Pediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3761
Abstract: Renal transplantation (RTx) is an effective therapy to improve clinical outcomes in pediatric patients with terminal chronic kidney disease. However, chronic immunosuppression with glucocorticoids (GCs) reduces bone growth and BMD. The mechanisms causing GC‐induced growth… read more here.
Keywords: fgf23; bone growth; bone; expression ... See more keywords
Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4248
Abstract: Endochondral ossification is tightly controlled by a coordinated network of signaling cascades including parathyroid hormone (PTH). Pleckstrin homology (PH) domain and leucine rich repeat phosphatase 1 (Phlpp1) affects endochondral ossification by suppressing chondrocyte proliferation in… read more here.
Keywords: pth; phlpp1; pth1r expression; bone growth ... See more keywords
Laser Sintered Porous Ti–6Al–4V Implants Stimulate Vertical Bone Growth
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-017-1831-7
Abstract: The objective of this study was to examine the ability of 3D implants with trabecular-bone-inspired porosity and micro-/nano-rough surfaces to enhance vertical bone ingrowth. Porous Ti–6Al–4V constructs were fabricated via laser-sintering and processed to obtain micro-/nano-rough surfaces.… read more here.
Keywords: vertical bone; laser; bone growth; bone ... See more keywords
Radial Shockwave Treatment Promotes Chondrogenesis in Human Growth Plate and Longitudinal Bone Growth in Rabbits.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116186
Abstract: OBJECTIVE The process of longitudinal bone growth occurs at the growth plate where the chondrocytes undergo apparent structural and molecular changes to promote growth. Recent reports suggest that radial shockwave treatment (rSWT) stimulates bone length… read more here.
Keywords: growth plate; longitudinal bone; human growth; bone growth ... See more keywords
Validation of an in vivo micro-CT-based method to quantify longitudinal bone growth of pubertal rats.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116207
Abstract: Bone growth is an essential part of skeletal development during childhood and puberty. Accurately characterizing longitudinal bone growth helps to better understand the determining factors of peak bone mass, which has impacts on bone quality… read more here.
Keywords: longitudinal bone; bone growth; based method; growth ... See more keywords
Effect of periosteal resection on longitudinal bone growth in a mouse model of achondroplasia
Sign Up to like & getrecommendations! Published in 2020 at "Bone Reports"
DOI: 10.1016/j.bonr.2020.100708
Abstract: Achondroplasia (ACH) is the most common form of short-limbed skeletal dysplasia. Patients with ACH sometimes undergo lower limb lengthening to get functional and psychological achievements. The periosteal resection (PR) is a known mechanism to increase… read more here.
Keywords: longitudinal bone; bone growth; bone; mice ... See more keywords
Image-based modelling for Adolescent Idiopathic Scoliosis: Mechanistic machine learning analysis and prediction
Sign Up to like & getrecommendations! Published in 2021 at "Computer Methods in Applied Mechanics and Engineering"
DOI: 10.1016/j.cma.2020.113590
Abstract: Abstract Scoliosis, an abnormal curvature of the human spinal column, is characterized by a lateral deviation of the spine, accompanied by axial rotation of the vertebrae. Adolescent Idiopathic Scoliosis (AIS) is the most common type,… read more here.
Keywords: adolescent idiopathic; bone growth; scoliosis; growth ... See more keywords
The influence of macro-textural designs over implant surface on bone on-growth: A computational mechanobiology based study
Sign Up to like & getrecommendations! Published in 2020 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2020.103937
Abstract: The longerterm secondary stability of an uncemented implant depends primarily on the quality and extent of bone in-growth or on-growth at the bone-implant interface. Investigations are warranted to predict the influences of implant macro-textures on… read more here.
Keywords: study; bone growth; bone; influence macro ... See more keywords
Zoledronic Acid Implant Coating Results in Local Medullary Bone Growth
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00644
Abstract: Osteoarthritis (OA) can necessitate surgical interventions to restore the function of the joint in severe cases. Joint replacement surgery is one of the procedures implemented to replace the damaged joint with prosthetic implants in severe… read more here.
Keywords: growth; bone; zoledronic acid; bone growth ... See more keywords
Functional interaction between Wnt and Bmp signaling in periosteal bone growth
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90324-1
Abstract: Wnt and Bmp proteins are well known to regulate bone development and homeostasis. Although both signals are extensively studied, their potential interaction in vivo is less well understood. Previous studies have shown that deletion of… read more here.
Keywords: periosteal bone; bmp signaling; wnt; bone growth ... See more keywords