Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13963
Abstract: Dynamin‐related protein 1 (DRP1) is a mitochondrial membrane GTPase and regulates mitochondrial fission. In this study, we found that the cytokine RANKL increased the expression of DRP1 and its receptor proteins, Fis1, Mid49, and Mid… read more here.
Keywords: osteoclast differentiation; differentiation; bone loss; related protein ... See more keywords
A Multifunctional Therapeutic Strategy Using P7C3 as A Countermeasure Against Bone Loss and Fragility in An Ovariectomized Rat Model of Postmenopausal Osteoporosis
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202308698
Abstract: By 2060, an estimated one in four Americans will be elderly. Consequently, the prevalence of osteoporosis and fragility fractures will also increase. Presently, no available intervention definitively prevents or manages osteoporosis. This study explores whether… read more here.
Keywords: bone; bone loss; multifunctional therapeutic; loss fragility ... See more keywords
Natural Affinity Driven Modification by Silicene to Construct a “Thermal Switch” for Tumorous Bone Loss
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DOI: 10.1002/advs.202404534
Abstract: Tumorous bone defects present significant challenges for surgical bio‐reconstruction due to the dual pathological conditions of residual tumor presence and extensive bone loss following excision surgery. To address this challenge, a “thermal switch” smart bone… read more here.
Keywords: bone; bone loss; tumorous bone; thermal switch ... See more keywords
Evaluation of Panoramic Radiography Diagnostic Accuracy in the Assessment of Interdental Alveolar Bone Loss Using CBCT
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Experimental Dental Research"
DOI: 10.1002/cre2.70042
Abstract: Alveolar bone loss (ABL) and periodontal lesions are common diseases that have an undeniable effect on teeth maintenance and health. Current diagnostic methods include probing, intraoral radiography, and panoramic radiography; each has its limitations. In… read more here.
Keywords: diagnostic accuracy; bone loss; panoramic radiography; radiography ... See more keywords
AOP Report: Development of an adverse outcome pathway for deposition of energy leading to bone loss
Sign Up to like & getrecommendations! Published in 2024 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22631
Abstract: Bone loss, commonly seen in osteoporosis, is a condition that entails a progressive decline of bone mineral density and microarchitecture, often seen in post‐menopausal women. Bone loss has also been widely reported in astronauts exposed… read more here.
Keywords: bone loss; adverse outcome; loss; development ... See more keywords
Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3072
Abstract: Chemerin is an adipokine that regulates adipogenesis and metabolic functions of mature adipocytes mainly through the activation of chemokine‐like receptor 1 (CMKLR1). Elevated levels of chemerin have been found in individuals with obesity, type 2… read more here.
Keywords: bone; adipokine; mice; bone loss ... See more keywords
Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3224
Abstract: Age‐dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age‐associated increase in the generation of reactive oxygen species has been frequently implicated.… read more here.
Keywords: kynurenine; age; bone; kyn ... See more keywords
Effects of Teriparatide and Vibration on Bone Mass and Bone Strength in People with Bone Loss and Spinal Cord Injury: A Randomized, Controlled Trial
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3525
Abstract: Spinal cord injury (SCI) is associated with marked bone loss and an increased risk of fracture. We randomized 61 individuals with chronic SCI and low bone mass to receive either teriparatide 20 μg/d plus sham vibration… read more here.
Keywords: vibration; bone; bone mass; bone loss ... See more keywords
A Novel Rhein Derivative Modulates Bone Formation and Resorption and Ameliorates Estrogen‐Dependent Bone Loss
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3604
Abstract: Osteoporosis, an osteolytic disease that affects millions of people worldwide, features a bone remodeling imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Identifying dual target‐directed agents that inhibit excessive bone resorption and… read more here.
Keywords: bone; bone formation; bone loss; resorption ... See more keywords
Fra1 Controls Rheumatoid Factor Autoantibody Production by Bone Marrow Plasma Cells and the Development of Autoimmune Bone Loss
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3705
Abstract: Next to proinflammatory cytokines, autoimmunity has been identified as a key trigger for osteoclast activation and bone loss. IgG‐rheumatoid factor (IgG‐RF) immune complexes, which are present in patients with rheumatoid arthritis, were shown to boost… read more here.
Keywords: production; bone; plasma cells; bone loss ... See more keywords
Zoledronate for the Prevention of Bone Loss in Women Discontinuing Denosumab Treatment. A Prospective 2‐Year Clinical Trial
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3853
Abstract: Cessation of denosumab treatment is associated with increases in bone turnover above baseline values and rapid bone loss. We investigated the efficacy of zoledronate to prevent this bone loss in women with postmenopausal osteoporosis who… read more here.
Keywords: zoledronate; treatment; group; bone ... See more keywords