Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss
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DOI: 10.1002/1873-3468.13963
Abstract: Dynamin‐related protein 1 (DRP1) is a mitochondrial membrane GTPase and regulates mitochondrial fission. In this study, we found that the cytokine RANKL increased the expression of DRP1 and its receptor proteins, Fis1, Mid49, and Mid… read more here.
Keywords: osteoclast differentiation; differentiation; bone loss; related protein ... See more keywords
Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3072
Abstract: Chemerin is an adipokine that regulates adipogenesis and metabolic functions of mature adipocytes mainly through the activation of chemokine‐like receptor 1 (CMKLR1). Elevated levels of chemerin have been found in individuals with obesity, type 2… read more here.
Keywords: bone; adipokine; mice; bone loss ... See more keywords
Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3224
Abstract: Age‐dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age‐associated increase in the generation of reactive oxygen species has been frequently implicated.… read more here.
Keywords: kynurenine; age; bone; kyn ... See more keywords
Effects of Teriparatide and Vibration on Bone Mass and Bone Strength in People with Bone Loss and Spinal Cord Injury: A Randomized, Controlled Trial
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DOI: 10.1002/jbmr.3525
Abstract: Spinal cord injury (SCI) is associated with marked bone loss and an increased risk of fracture. We randomized 61 individuals with chronic SCI and low bone mass to receive either teriparatide 20 μg/d plus sham vibration… read more here.
Keywords: vibration; bone; bone mass; bone loss ... See more keywords
A Novel Rhein Derivative Modulates Bone Formation and Resorption and Ameliorates Estrogen‐Dependent Bone Loss
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3604
Abstract: Osteoporosis, an osteolytic disease that affects millions of people worldwide, features a bone remodeling imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Identifying dual target‐directed agents that inhibit excessive bone resorption and… read more here.
Keywords: bone; bone formation; bone loss; resorption ... See more keywords
Fra1 Controls Rheumatoid Factor Autoantibody Production by Bone Marrow Plasma Cells and the Development of Autoimmune Bone Loss
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3705
Abstract: Next to proinflammatory cytokines, autoimmunity has been identified as a key trigger for osteoclast activation and bone loss. IgG‐rheumatoid factor (IgG‐RF) immune complexes, which are present in patients with rheumatoid arthritis, were shown to boost… read more here.
Keywords: production; bone; plasma cells; bone loss ... See more keywords
Zoledronate for the Prevention of Bone Loss in Women Discontinuing Denosumab Treatment. A Prospective 2‐Year Clinical Trial
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3853
Abstract: Cessation of denosumab treatment is associated with increases in bone turnover above baseline values and rapid bone loss. We investigated the efficacy of zoledronate to prevent this bone loss in women with postmenopausal osteoporosis who… read more here.
Keywords: zoledronate; treatment; group; bone ... See more keywords
BMP9 Reduces Bone Loss in Ovariectomized Mice by Dual Regulation of Bone Remodeling
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DOI: 10.1002/jbmr.3957
Abstract: Bone remodeling is dynamic and is tightly regulated through bone resorption dominated by osteoclasts and bone formation dominated by osteoblasts. Imbalances in this process can cause various pathological conditions, such as osteoporosis. Bone morphogenetic protein… read more here.
Keywords: bmp9; bone; bone loss; bone remodeling ... See more keywords
Osteoporosis and Dementia: Establishing a Link
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DOI: 10.1002/jbmr.4431
Abstract: Patients with dementia often fall and frequently fracture. Alzheimer’s disease (AD) is the most prevalent form of dementia, and patients with AD often have profound changes in body composition as the disease progresses, including the… read more here.
Keywords: risk; fracture; dementia; decline ... See more keywords
Anti‐Mullerian Hormone as Predictor of Future and Ongoing Bone Loss During the Menopause Transition
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DOI: 10.1002/jbmr.4525
Abstract: The menopause transition in women is a period of significant bone loss, with rapid declines in bone mineral density (BMD) commencing a year before the final menstrual period (FMP). Changes in menstrual bleeding patterns cannot… read more here.
Keywords: menopause transition; bone loss; bone; loss ... See more keywords
Bone Marrow Adiposity in Models of Radiation‐ and Aging‐Related Bone Loss Is Dependent on Cellular Senescence
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DOI: 10.1002/jbmr.4537
Abstract: Oxidative stress‐induced reactive oxygen species, DNA damage, apoptosis, and cellular senescence have been associated with reduced osteoprogenitors in a reciprocal fashion to bone marrow adipocyte tissue (BMAT); however, a direct (causal) link between cellular senescence… read more here.
Keywords: bone marrow; bone; bmat; bone loss ... See more keywords