Targeting Histone Modifications in Bone and Lung Metastatic Cancers
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DOI: 10.1007/s11914-021-00670-2
Abstract: Breast cancer frequently metastasizes to the bone and lung, but the ability to treat metastatic tumor cells remains a pressing clinical challenge. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) have emerged as promising targets since… read more here.
Keywords: bone lung; hdac inhibitors; metastatic cancers; lung metastatic ... See more keywords
The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64018-z
Abstract: The most challenging issue for breast cancer (BC) patients is metastasis to other organs because current therapies do not prevent or eliminate metastatic BC. Here, we show that SM-164, a small molecule inhibitor, which degrades… read more here.
Keywords: breast; bone lung; breast cancer; metastasis ... See more keywords