Microfluidic enrichment of plasma cells improves treatment of multiple myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12201
Abstract: Cytogenetic alterations form the basis for risk stratification for multiple myeloma (MM) and guide the selection of therapy; however, current pathology assays performed on bone marrow samples can produce false‐negatives due to the unpredictable distribution… read more here.
Keywords: cytogenetic alterations; multiple myeloma; plasma cells; cd45 ... See more keywords
Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12768
Abstract: Myelodysplastic syndromes (MDS) are preleukemic disorders characterized by clonal growth of mutant hematopoietic stem and progenitor cells. MDS are associated with proinflammatory signaling, dysregulated immune response, and cell death in the bone marrow (BM). Aging,… read more here.
Keywords: myelodysplastic syndromes; candidate biomarker; bone marrow;
METTL3 mediates bone marrow mesenchymal stem cell adipogenesis to promote chemoresistance in acute myeloid leukaemia
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13165
Abstract: Adipogenesis of bone marrow mesenchymal stem cells (MSCs) promotes chemoresistance of acute myeloid leukaemia (AML) cells. MSCs from AML patients (AML‐MSCs) display enhanced adipogenesis compared with bone marrow MSCs from healthy donors. However, the precise… read more here.
Keywords: adipogenesis; chemoresistance acute; bone marrow; marrow mesenchymal ... See more keywords
A comparative study of mouse bone marrow mesenchymal stem cells isolated using three easy‐to‐perform approaches
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13493
Abstract: Mouse bone marrow mesenchymal stem cells (mBM‐MSCs) are important for preclinical tissue regeneration and repair studies. In the present study, we isolated mBM‐MSCs using three easy‐to‐perform methods (whole bone marrow‐adherent culture, density‐gradient centrifugation, and bone… read more here.
Keywords: marrow mesenchymal; bone marrow; bone; mouse bone ... See more keywords
Carbonate Apatite Micro‐Honeycombed Blocks Generate Bone Marrow‐Like Tissues as well as Bone
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Biosystems"
DOI: 10.1002/adbi.201900140
Abstract: Hematopoietic stem cells form blood cells in bone marrow and reside in niches. Artificial environments that conserve these niches may generate bone marrow. Osteogenesis, angiogenesis, and material resorption must be regulated to create these environments.… read more here.
Keywords: like tissues; generate bone; bone; carbonate apatite ... See more keywords
Bone Marrow Mesenchymal Stem Cell-Derived Dermcidin-Containing Migrasomes enhance LC3-Associated Phagocytosis of Pulmonary Macrophages and Protect against Post-Stroke Pneumonia.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206432
Abstract: Pneumonia is one of the leading causes of death in patients with acute ischemic stroke (AIS). Antibiotics fail to improve prognosis of patients with post-stroke pneumonia, albeit suppressing infection, due to adverse impacts on the… read more here.
Keywords: bone marrow; post stroke; phagocytosis; stroke pneumonia ... See more keywords
Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38-Targeted Lipid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301377
Abstract: Multiple myeloma (MM) is a cancer of differentiated plasma cells that occurs in the bone marrow (BM). Despite the recent advancements in drug development, most patients with MM eventually relapse and the disease remains incurable.… read more here.
Keywords: lipid nanoparticles; bone marrow; cd38; rna ... See more keywords
IKAROS expression in distinct bone marrow cell populations as a candidate biomarker for outcome with lenalidomide‐dexamethasone therapy in multiple myeloma
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24634
Abstract: Immunomodulatory drugs (IMiDs) are a cornerstone in the treatment of multiple myeloma (MM), but specific markers to predict outcome are still missing. Recent work pointed to a prognostic role for IMiD target genes (e.g. CRBN).… read more here.
Keywords: cell populations; multiple myeloma; expression; lenalidomide dexamethasone ... See more keywords
Fat embolism syndrome due to bone marrow necrosis in patients with hemoglobinopathies: A life‐threatening complication mimicking thrombotic thrombocytopenic purpura
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25363
Abstract: To the Editor: Bone marrow necrosis (BMN) and embolization of fat and necrotic marrow is a rare, life-threatening condition in patients with sickle cell disorders (SCD). Fat emboli cause multiorgan failure with anemia and thrombocytopenia,… read more here.
Keywords: marrow necrosis; life threatening; ttp; mimicking thrombotic ... See more keywords
Imaging and bone marrow assessments improve minimal residual disease prediction in multiple myeloma
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25507
Abstract: The value of minimal residual disease (MRD) status by bone marrow and imaging analysis as independent prognostic factors has been well established in multiple myeloma (MM). Nevertheless data about their potential complementarity for a more… read more here.
Keywords: pet; mrd pet; minimal residual; residual disease ... See more keywords
Bone marrow blast elimination by the fifth day of 7 + 3 induction is the strongest predictor of potential cure in patients with acute myeloid leukemia younger than 61 years of age: A long‐term follow‐up of a multi‐center prospective study
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25651
Abstract: S.Orsola-Malpighi di Bologna, Bologna, Italy Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy Hematology Department, San Bortolo Hospital, Vicenza, Italy Richard T. Silver Myeloproliferative Neoplasms Center, Weill Cornell Medical… read more here.
Keywords: medicine; hematology; varese italy; marrow blast ... See more keywords