Microfluidic enrichment of plasma cells improves treatment of multiple myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12201
Abstract: Cytogenetic alterations form the basis for risk stratification for multiple myeloma (MM) and guide the selection of therapy; however, current pathology assays performed on bone marrow samples can produce false‐negatives due to the unpredictable distribution… read more here.
Keywords: cytogenetic alterations; multiple myeloma; plasma cells; cd45 ... See more keywords
Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12768
Abstract: Myelodysplastic syndromes (MDS) are preleukemic disorders characterized by clonal growth of mutant hematopoietic stem and progenitor cells. MDS are associated with proinflammatory signaling, dysregulated immune response, and cell death in the bone marrow (BM). Aging,… read more here.
Keywords: myelodysplastic syndromes; candidate biomarker; bone marrow;
PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular oncology"
DOI: 10.1002/1878-0261.70120
Abstract: Despite significant advancements, multiple myeloma (MM) remains incurable, largely due to drug resistance. Our previous research has demonstrated that proline metabolism plays a role in MM progression and that inhibiting PYCR1, the final enzyme in… read more here.
Keywords: multiple myeloma; enhances bortezomib; metabolism; bone marrow ... See more keywords
METTL3 mediates bone marrow mesenchymal stem cell adipogenesis to promote chemoresistance in acute myeloid leukaemia
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13165
Abstract: Adipogenesis of bone marrow mesenchymal stem cells (MSCs) promotes chemoresistance of acute myeloid leukaemia (AML) cells. MSCs from AML patients (AML‐MSCs) display enhanced adipogenesis compared with bone marrow MSCs from healthy donors. However, the precise… read more here.
Keywords: adipogenesis; chemoresistance acute; bone marrow; marrow mesenchymal ... See more keywords
A comparative study of mouse bone marrow mesenchymal stem cells isolated using three easy‐to‐perform approaches
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13493
Abstract: Mouse bone marrow mesenchymal stem cells (mBM‐MSCs) are important for preclinical tissue regeneration and repair studies. In the present study, we isolated mBM‐MSCs using three easy‐to‐perform methods (whole bone marrow‐adherent culture, density‐gradient centrifugation, and bone… read more here.
Keywords: marrow mesenchymal; bone marrow; bone; mouse bone ... See more keywords
Carbonate Apatite Micro‐Honeycombed Blocks Generate Bone Marrow‐Like Tissues as well as Bone
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Biosystems"
DOI: 10.1002/adbi.201900140
Abstract: Hematopoietic stem cells form blood cells in bone marrow and reside in niches. Artificial environments that conserve these niches may generate bone marrow. Osteogenesis, angiogenesis, and material resorption must be regulated to create these environments.… read more here.
Keywords: like tissues; generate bone; bone; carbonate apatite ... See more keywords
Influence of Hypoxia on a Biomaterial Model of the Bone Marrow Perivascular Niche
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202500858
Abstract: Hematopoietic stem cell (HSC) fate is shaped by distinct microenvironments termed niches within the bone marrow. Quiescence, expansion, and differentiation are directly and indirectly regulated by complex combinations of cell secretomes, cell-cell interactions, mechanical signals,… read more here.
Keywords: bone marrow; model bone; perivascular niche; culture ... See more keywords
Bioactive Materials-Mediated Regulation of Bone Marrow Microenvironment: Mechanistic Insights and Therapeutic Potentials.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced materials"
DOI: 10.1002/adma.202511497
Abstract: The bone marrow microenvironment(BME) maintains bone homeostasis through multi‐cellular cooperation and signal crosstalk, its dysregulation drives pathological bone loss. In recent years, Materiobiology, a scientific discipline studying how biomaterial properties affect biological functions, has opened… read more here.
Keywords: bone; marrow microenvironment; regulation; bone marrow ... See more keywords
Bone Marrow Mesenchymal Stem Cell-Derived Dermcidin-Containing Migrasomes enhance LC3-Associated Phagocytosis of Pulmonary Macrophages and Protect against Post-Stroke Pneumonia.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206432
Abstract: Pneumonia is one of the leading causes of death in patients with acute ischemic stroke (AIS). Antibiotics fail to improve prognosis of patients with post-stroke pneumonia, albeit suppressing infection, due to adverse impacts on the… read more here.
Keywords: bone marrow; post stroke; phagocytosis; stroke pneumonia ... See more keywords
Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38-Targeted Lipid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301377
Abstract: Multiple myeloma (MM) is a cancer of differentiated plasma cells that occurs in the bone marrow (BM). Despite the recent advancements in drug development, most patients with MM eventually relapse and the disease remains incurable.… read more here.
Keywords: lipid nanoparticles; bone marrow; cd38; rna ... See more keywords
Targeting Bacteria‐Induced Ferroptosis of Bone Marrow Mesenchymal Stem Cells to Promote the Repair of Infected Bone Defects
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202404453
Abstract: The specific mechanisms underlying bacteria‐triggered cell death and osteogenic dysfunction in host bone marrow mesenchymal stem cells (BMSCs) remain unclear, posing a significant challenge to the repair of infected bone defects. This study identifies ferroptosis… read more here.
Keywords: bone marrow; repair; ferroptosis; infected bone ... See more keywords