High bone mass in mice can be linked to lower osteoclast formation, resorptive capacity, and restricted in vitro sensitivity to inhibition by stable sulforaphane
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3734
Abstract: Mouse strains can have divergent basal bone mass, yet this phenotype is seldom reflected in the design of studies seeking to identify new modulators of bone resorption by osteoclasts. Sulforaphane exerts inhibitory effects on in… read more here.
Keywords: inhibition; sensitivity; bone mass; mice ... See more keywords
Perinatal DNA Methylation at CDKN2A Is Associated With Offspring Bone Mass: Findings From the Southampton Women's Survey
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DOI: 10.1002/jbmr.3153
Abstract: Poor intrauterine and childhood growth has been linked with the risk of osteoporosis in later life, a relationship that may in part be mediated through altered epigenetic regulation of genes. We previously identified a region… read more here.
Keywords: methylation; cdkn2a; bone; bone mass ... See more keywords
Effects of Teriparatide and Vibration on Bone Mass and Bone Strength in People with Bone Loss and Spinal Cord Injury: A Randomized, Controlled Trial
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3525
Abstract: Spinal cord injury (SCI) is associated with marked bone loss and an increased risk of fracture. We randomized 61 individuals with chronic SCI and low bone mass to receive either teriparatide 20 μg/d plus sham vibration… read more here.
Keywords: vibration; bone; bone mass; bone loss ... See more keywords
Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis
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DOI: 10.1002/jbmr.4046
Abstract: The impact of primary hand osteoarthritis (HOA) on bone mass, microstructure, and biomechanics in the affected skeletal regions is largely unknown. HOA patients and healthy controls (HCs) underwent high‐resolution peripheral quantitative computed tomography (HR‐pQCT). We… read more here.
Keywords: vbmd; biomechanics; bone; hoa ... See more keywords
Response of the ENPP1‐Deficient Skeletal Phenotype to Oral Phosphate Supplementation and/or Enzyme Replacement Therapy: Comparative Studies in Humans and Mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4254
Abstract: Inactivating mutations in human ecto‐nucleotide pyrophosphatase/phosphodiesterase‐1 (ENPP1) may result in early‐onset osteoporosis (EOOP) in haploinsufficiency and autosomal recessive hypophosphatemic rickets (ARHR2) in homozygous deficiency. ARHR2 patients are frequently treated with phosphate supplementation to ameliorate the… read more here.
Keywords: enpp1; bone; bone mass; arhr2 patients ... See more keywords
Catalysis‐Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4640
Abstract: Biallelic ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) deficiency induces vascular/soft tissue calcifications in generalized arterial calcification of infancy (GACI), and low bone mass with phosphate‐wasting rickets in GACI survivors (autosomal hypophosphatemic rickets type‐2). ENPP1 haploinsufficiency induces early‐onset… read more here.
Keywords: catalysis; catalysis independent; bone; independent enpp1 ... See more keywords
Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4733
Abstract: Vector‐borne infections of humans with the protozoan parasite Leishmania (L.) infantum can cause a systemic and potentially lethal disease termed visceral leishmaniasis. In the corresponding mouse model, an intravenous infection with L. infantum leads to… read more here.
Keywords: infantum; bone; infection; leishmania ... See more keywords
Reduced Peak Bone Mass in Young Adults With Low Motor Competence
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4788
Abstract: Although suboptimal bone health has been reported in children and adolescents with low motor competence (LMC), it is not known whether such deficits are present at the time of peak bone mass. We examined the… read more here.
Keywords: bone; physical activity; bone mass; motor competence ... See more keywords
Rare and Common Variants in GALNT3 May Affect Bone Mass Independently of Phosphate Metabolism
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4795
Abstract: Anabolic treatment options for osteoporosis remain limited. One approach to discovering novel anabolic drug targets is to identify genetic causes of extreme high bone mass (HBM). We investigated a pedigree with unexplained HBM within the… read more here.
Keywords: variants galnt3; galnt3; hbm; bone mass ... See more keywords
Gulp1 deficiency augments bone mass in male mice by affecting osteoclasts due to elevated 17β‐estradiol levels
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30987
Abstract: The engulfment adaptor phosphotyrosine‐binding domain containing 1 (GULP1) is an adaptor protein involved in the engulfment of apoptotic cells via phagocytosis. Gulp1 was first found to promote the phagocytosis of apoptotic cells by macrophages, and… read more here.
Keywords: bone mass; gulp1; male; mice ... See more keywords
Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2944-3
Abstract: The adipokine Chemerin and its receptor, chemokine-like receptor 1 (CMKLR1), are associated with osteoblastogenic differentiation of mesenchymal stem cells (MSCs) and osteoclastogenic differentiation of osteoclast precursors in vitro, suggesting that CMKLR1 would affect the bone… read more here.
Keywords: cmklr1; male mice; bone; bone mass ... See more keywords