Duration‐Dependent Increase of Human Bone Matrix Mineralization in Long‐Term Bisphosphonate Users with Atypical Femur Fracture
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4244
Abstract: Bisphosphonates (BPs) are the most widely used drugs for the treatment of osteoporosis but prolonged use of BPs might increase the risk of atypical femur fracture (AFF). There are only a few studies that address… read more here.
Keywords: aff; long term; bone matrix; duration ... See more keywords
Calcimimetics Alter Periosteal and Perilacunar Bone Matrix Composition and Material Properties in Early Chronic Kidney Disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4574
Abstract: Chronic kidney disease (CKD) affects 15% of Americans and greatly increases fracture risk due to elevated parathyroid hormone, cortical porosity, and reduced bone material quality. Calcimimetic drugs are used to lower parathyroid hormone (PTH) in… read more here.
Keywords: perilacunar bone; bone matrix; bone; ckd ... See more keywords
Improved physical and osteoinductive properties of demineralized bone matrix by gelatin methacryloyl formulation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.3012
Abstract: The demineralized bone matrix (DBM) is the most widely used bone allograft, which is obtained by removing the mineral component of bone, leading to exposure of the proteins responsible for osteoinduction. For clinical use, DBM… read more here.
Keywords: demineralized bone; dbm; bone matrix; gelatin methacryloyl ... See more keywords
Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-017-0844-5
Abstract: Bone loss varies according to disease and age and these variations affect bone cells and extracellular matrix. Osteoporosis rat models are widely investigated to assess mechanical and structural properties of bone; however, bone matrix proteins… read more here.
Keywords: computational segmentation; segmentation collagen; matrix; bone matrix ... See more keywords
Clinical Importance of Bone Matrix Damage Mechanisms for Fracture Prevention
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DOI: 10.1007/s11914-021-00678-8
Abstract: Bone matrix exhibits great complexity in its composition, structure and mechanics. Here, we provide a review of recent research articles and appraise the evidence that bone matrix quality is clinically important and possibly targetable for… read more here.
Keywords: fracture prevention; matrix; bone matrix; bone ... See more keywords
Control of osteoblast arrangement by osteocyte mechanoresponse through prostaglandin E2 signaling under oscillatory fluid flow stimuli.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.121203
Abstract: Anisotropic collagen/apatite microstructure is a prominent determinant of bone tissue functionalization; in particular, bone matrix modulates its anisotropic microstructure depending on the surrounding mechanical condition. Although mechanotransduction in bones is governed by osteocyte function, the… read more here.
Keywords: bone matrix; bone; osteoblast arrangement; flow stimuli ... See more keywords
The Budget Impact of Introducing Demineralised Bone Matrix Combined with Local Bone to Replace Currently Available Treatments for Lumbar Spinal Fusion Procedures in Spain
Sign Up to like & getrecommendations! Published in 2017 at "Value in Health"
DOI: 10.1016/j.jval.2017.08.744
Abstract: Objectives: Estimate the budget impact (BI) of introducing demineralised bone matrix (DBM) combined with local bone (LB) in lumbar spinal fusion to treat lumbar degenerative disk disease in Spain. ... read more here.
Keywords: impact introducing; budget impact; bone matrix; demineralised bone ... See more keywords
Analysis of cobalt deposition in periprosthetic bone specimens by high-resolution synchroton XRF in undecalcified histological thin sections
Sign Up to like & getrecommendations! Published in 2019 at "Materialia"
DOI: 10.1016/j.mtla.2019.100290
Abstract: Abstract Increasing numbers of implant revisions are a current clinical issue. Interactions of the endoprosthesis biomaterial with the body affect implantation time by wear processes, i.e. corrosion and abrasion. Previously, cobalt-chrome implants were shown to… read more here.
Keywords: xrf; bone matrix; thin sections; undecalcified histological ... See more keywords
Gaucher disease iPSC-derived osteoblasts have developmental and lysosomal defects that impair bone matrix deposition
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx442
Abstract: Gaucher disease (GD) is caused by bi-allelic mutations in GBA1, the gene that encodes acid β-glucocerebrosidase (GCase). Individuals affected by GD have hematologic, visceral and bone abnormalities, and in severe cases there is also neurodegeneration.… read more here.
Keywords: matrix deposition; bone matrix; deposition; bone ... See more keywords
Demineralized Bone Matrix Carriers and their Clinical Applications: An Overview
Sign Up to like & getrecommendations! Published in 2019 at "Orthopaedic Surgery"
DOI: 10.1111/os.12509
Abstract: Reconstruction of massive bone defects is challenging for orthopaedic clinicians, especially in cases of severe trauma and resection of tumors in various locales. Autologous iliac crest bone graft (ICBG) is the “gold standard” for bone… read more here.
Keywords: demineralized bone; matrix carriers; bone matrix; carriers clinical ... See more keywords
Demineralized bone matrix-based microcarrier scaffold favors vascularized large bone regeneration in vivo in a rat model
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomaterials Applications"
DOI: 10.1177/0885328218784370
Abstract: Insufficient neo-vascularization of in vivo implanted cell-seeded scaffold remains a major bottleneck for clinical translation of engineered bone formation. Demineralized bone matrix is an ideal bone scaffold for bone engineering due to its structural and… read more here.
Keywords: demineralized bone; bone regeneration; bone matrix; bone ... See more keywords