Bone Microenvironment‐Suppressed T Cells Increase Osteoclast Formation and Osteolytic Bone Metastases in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4615
Abstract: Immunotherapies use components of the immune system, such as T cells, to fight cancer cells, and are changing cancer treatment, causing durable responses in some patients. Bone metastases are a debilitating complication in advanced breast… read more here.
Keywords: cell; osteoclast formation; bone; bone metastases ... See more keywords
Contributions of the Bone Microenvironment to Monoclonal Gammopathy of Undetermined Significance Pathogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-018-0479-z
Abstract: Purpose of ReviewMGUS (monoclonal gammopathy of undetermined significance) is a plasma cell disorder characterized by a moderate increase in serum monoclonal protein (≤ 3 g/dL), an increase in bone marrow plasma cell infiltration (≤ 10%) and the absence… read more here.
Keywords: monoclonal gammopathy; undetermined significance; gammopathy undetermined; bone microenvironment ... See more keywords
Emerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone microenvironment engineering.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d2sm00009a
Abstract: Bone presents an intrinsic ability for self-regeneration and repair, however critical defects and large fractures require invasive and time-consuming clinical interventions. As an alternative to current therapy, bone tissue engineering (BTE) has primarily aimed to… read more here.
Keywords: bone; osteogenic differentiation; emerging modulators; bone microenvironment ... See more keywords
Abstract 2116: Tumor-specific effects of estrogen drive a murine model of human estrogen receptor-positive breast cancer bone metastasis independent of bone microenvironment changes
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2116
Abstract: Estrogen receptor α-positive (ER+) breast cancers (BrCAs) have the greatest predilection for forming bone metastases (BMETs). To begin to query ERα9s role in osteolytic BrCA BMET progression, tumoral vs bone microenvironment effects of 17β-estradiol (E2)… read more here.
Keywords: receptor positive; bone; bone microenvironment; cancer ... See more keywords
Abstract 2382: Three-dimensional spatial phenotyping of cellular landscapes in the bone microenvironment of spontaneous metastases
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2382
Abstract: Metastasis to distant organs is the major cause of cancer-related deaths, and bone is the most frequent destination of metastasis in many cancers. Recent studies have shown that the bone microenvironment, not only permits, but… read more here.
Keywords: cell; dimensional spatial; three dimensional; spatial relationships ... See more keywords
Drug Delivery to the Bone Microenvironment Mediated by Exosomes: An Axiom or Enigma
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s307843
Abstract: Abstract The increasing incidence of bone-related disorders is causing a burden on the clinical scenario. Even though bone is one of the tissues that possess tremendous regenerative potential, certain bone anomalies need therapeutic intervention through… read more here.
Keywords: delivery; bone microenvironment; drug delivery; bone ... See more keywords
Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1023231
Abstract: As bone biology develops, it is gradually recognized that bone regeneration is a pathophysiological process that requires the simultaneous participation of multiple systems. With the introduction of osteoimmunology, the interplay between the immune system and… read more here.
Keywords: microenvironment engineering; multidimensional biomaterials; bone; functionalized multidimensional ... See more keywords
The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1123065
Abstract: Osteosarcoma is a primary bone tumor with a high mortality rate. The event-free survival rate has not improved significantly in the past 30 years, which brings a heavy burden to patients and society. The high… read more here.
Keywords: clinical applications; osteosarcoma; microenvironment; cells bone ... See more keywords
Metabolic features of myeloma cells in the context of bone microenvironment: Implication for the pathophysiology and clinic of myeloma bone disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1015402
Abstract: Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of malignant plasma cells (PCs) into the bone marrow (BM). The complex interaction between the BM microenvironment and MM PCs can lead to severe… read more here.
Keywords: microenvironment; metabolic features; bone; myeloma ... See more keywords
Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22062911
Abstract: Metastasis to the bone is a common feature of many cancers including those of the breast, prostate, lung, thyroid and kidney. Once tumors metastasize to the bone, they are essentially incurable. Bone metastasis is a… read more here.
Keywords: dormancy; bone; bone microenvironment; growth ... See more keywords
The Role of Hedgehog Signaling in the Melanoma Tumor Bone Microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108862
Abstract: A crucial regulator in melanoma progression and treatment resistance is tumor microenvironments, and Hedgehog (Hh) signals activated in a tumor bone microenvironment are a potential new therapeutic target. The mechanism of bone destruction by melanomas… read more here.
Keywords: hedgehog; tumor bone; bone; tumor ... See more keywords