Suppressing phosphoinositide-specific phospholipases Cγ1 promotes mineralization of osteoarthritic subchondral bone osteoblasts via increasing autophagy, thereby ameliorating articular cartilage degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116262
Abstract: INTRODUCTION Phosphoinositide-specific phospholipases C-γ1 (PLC-γ1) signaling has been shown to modulate osteoarthritis (OA) chondrocyte metabolism. However, the role of PLC-γ1 in OA osteoblasts remains unclear. Herein, whether and how PLC-γ1 was involved in mineralization in… read more here.
Keywords: articular cartilage; subchondral bone; bone; bone osteoblasts ... See more keywords
A Numerical Study On Mechanical Effects of Low-intensity Pulsed Ultrasound On Trabecular Bone and Osteoblasts.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4056658
Abstract: The lack of sufficient mechanical stimulation to the human bone, results in disuse osteoporosis. Low-intensity pulsed ultrasound (LIPUS) promotes fracture healing and the treatment of disuse osteoporosis, but its biomechanical mechanism remains unknown. Simulative analyses… read more here.
Keywords: bone osteoblasts; disuse osteoporosis; bone; intensity pulsed ... See more keywords