Animal Models for the Study of Bone-Derived Pain.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8997-3_23
Abstract: Bone pain is a prevalent issue in society today and also is one of the hardest types of pain to control. Pain originating in the bone can be caused by many different entities including metastatic… read more here.
Keywords: study bone; models study; bone pain; animal models ... See more keywords
NOLAN: a randomized, phase 2 study to estimate the effect of prophylactic naproxen or loratadine vs no prophylactic treatment on bone pain in patients with early-stage breast cancer receiving chemotherapy and pegfilgrastim
Sign Up to like & getrecommendations! Published in 2017 at "Supportive Care in Cancer"
DOI: 10.1007/s00520-017-3959-2
Abstract: PurposeMild-to-moderate bone pain is a commonly reported adverse event (AE) associated with pegfilgrastim. We evaluated the effect of prophylactic naproxen or loratadine vs no prophylactic treatment on pegfilgrastim-associated bone pain.MethodsIn this open-label study (NCT01712009), women… read more here.
Keywords: treatment; naproxen loratadine; bone; pegfilgrastim ... See more keywords
An assessment of bone-seeking radionuclides for palliation of metastatic bone pain in a vertebral model
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Nuclear Medicine"
DOI: 10.1007/s12149-019-01329-w
Abstract: ObjectiveBone-seeking radiopharmaceuticals have the main role in the treatment of painful bone metastases. The aim of this study was to dosimetrically compare radiopharmaceuticals in use for bone pain palliation therapy and bone scan.MethodsThe MCNPX code… read more here.
Keywords: palliation; active marrow; bone; bone pain ... See more keywords
Developing drugs in cancer-related bone pain.
Sign Up to like & getrecommendations! Published in 2017 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2017.08.005
Abstract: INTRODUCTION Cancer-related bone pain is a frequent and important key problem for metastatic patients that may reduce quality of life, with related limitations in daily activities and morbidity. Often traditional approach to pain may fail… read more here.
Keywords: related bone; cancer related; pain; bone pain ... See more keywords
Prevalence of bone pain decreases as lymph node stage increases in nonsmall cell lung cancer patients.
Sign Up to like & getrecommendations! Published in 2019 at "Current problems in cancer"
DOI: 10.1016/j.currproblcancer.2018.08.006
Abstract: According to lung cancer guidelines, positron emission tomography scan is recommended for initial evaluation of bone metastasis. However, guidelines differ in their recommendations for when it should be used. We investigated the appropriate use of… read more here.
Keywords: bone metastases; bone pain; bone; bone metastasis ... See more keywords
Improving quality of life in patients with advanced cancer: Targeting metastatic bone pain.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cancer"
DOI: 10.1016/j.ejca.2016.10.021
Abstract: Metastatic bone disease in patients with advanced cancer is frequently associated with skeletal complications. These can be debilitating, causing pain, impaired functioning and decreased quality of life, as well as reduced survival. This review considers… read more here.
Keywords: metastatic bone; patients advanced; bone; cancer ... See more keywords
Sulforaphane alleviates hyperalgesia and enhances analgesic potency of morphine in rats with cancer-induced bone pain.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174412
Abstract: Due to the efficacy and tolerability of the available drugs, the current treatment for cancer-induced bone pain (CIBP) is not considered ideal, and new drugs are required for better treatment results. This study investigated whether… read more here.
Keywords: enhances analgesic; induced bone; bone; cancer ... See more keywords
Activation of the spinal EGFR signaling pathway in a rat model of cancer-induced bone pain with morphine tolerance
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108703
Abstract: Cancer-induced bone pain (CIBP) is considered to be one of the most difficult pain conditions to treat. Morphine, an analgesic drug, is widely used in clinical practice, and long-term use of morphine can lead to… read more here.
Keywords: tolerance; induced bone; cancer; bone pain ... See more keywords
Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.10.011
Abstract: Cancer-induced bone pain (CIBP) is a frequent complication in patients suffering from bone metastases. Previous studies have demonstrated a pivotal role of reactive oxygen species (ROS) in inflammatory and neuropathic pain, and ROS scavengers exhibited… read more here.
Keywords: cibp; induced bone; bone; cancer induced ... See more keywords
Glycogen synthase kinase‐3β inhibition decreases inflammation and relieves cancer induced bone pain via reducing Drp1‐mediated mitochondrial damage
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17432
Abstract: Bone is the preferential site of metastasis for breast cancer. Invasion of cancer cells induces the destruction of bone tissue and damnification of peripheral nerves and consequently induced central sensitization which contributes to severe pain.… read more here.
Keywords: bone; cancer induced; bone pain; cancer ... See more keywords
Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-15-3545
Abstract: Multiple myeloma patients experience severe bone pain (MMBP) that is undertreated and poorly understood. In this study, we studied MMBP in an intratibial mouse xenograft model that employs JJN3 human multiple myeloma cells. In this… read more here.
Keywords: atpase; asic3; multiple myeloma; bone ... See more keywords