Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption
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DOI: 10.1002/2211-5463.12258
Abstract: Abnormalities of bone turnover are commonly observed in patients with chronic kidney disease (CKD), and the low‐turnover bone disease is considered to be associated with low serum parathyroid hormone (PTH) levels and skeletal resistance to… read more here.
Keywords: bone formation; turnover; bone resorption; disease ... See more keywords
Sympathetic Innervation Regulates Osteocyte-Mediated Cortical Bone Resorption during Lactation.
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DOI: 10.1002/advs.202207602
Abstract: Bone undergoes constant remodeling by osteoclast bone resorption coupled with osteoblast bone formation at the bone surface. A third major cell type in the bone is osteocytes, which are embedded in the matrix, are well-connected… read more here.
Keywords: osteocyte mediated; bone; cortical bone; bone resorption ... See more keywords
An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice
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DOI: 10.1002/jbmr.3227
Abstract: The potent cathepsin K (CatK) inhibitor, Tanshinone IIA sulfonic sodium (T06), was tested for its in vitro and in vivo antiresorptive activities. T06 binds in an ectosteric site of CatK remote from its active site… read more here.
Keywords: inhibitor; bone resorption; cathepsin; site ... See more keywords
Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses
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DOI: 10.1002/jbmr.3428
Abstract: Exercise can cause a decrease in serum ionized calcium (iCa) and increases in parathyroid hormone (PTH) and bone resorption. We used a novel intravenous iCa clamp technique to determine whether preventing a decline in serum… read more here.
Keywords: bone resorption; serum; bone; ica ... See more keywords
Improved in vivo Experimental Screening Identifies an Anabolic Analog of 1,25 Dihydroxyvitamin D3 With Minimal Bone Resorption Activity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3933
Abstract: Although numerous strategies are available in the clinic to improve bone density and decrease risk of fractures by inhibiting osteoclasts number and action, few anabolic treatment options remain. The currently approved anabolic therapies, teriparatide, abaloparatide,… read more here.
Keywords: treatment; bone resorption; bone; calcium ... See more keywords
Achyranthes bidentata polysaccharide suppresses osteoclastogenesis and bone resorption via inhibiting RANKL signaling
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DOI: 10.1002/jcb.26682
Abstract: Osteoclasts are highly differentiated multinucleated giant cells that play fundamental roles in bone resorption and in the pathogenesis of osteolytic conditions, such as osteoporosis and cancer‐induced bone loss. Achyranthes bidentata polysaccharide (ABP) is a hydrophilic… read more here.
Keywords: bidentata polysaccharide; achyranthes bidentata; bone resorption; resorption ... See more keywords
Estrogen inhibits osteoclasts formation and bone resorption via microRNA‐27a targeting PPARγ and APC
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DOI: 10.1002/jcp.26788
Abstract: Inhibition of osteoclasts formation and bone resorption by estrogen is very important in the etiology of postmenopausal osteoporosis. The mechanisms of this process are still not fully understood. Recent studies implicated an important role of… read more here.
Keywords: bone resorption; estrogen; bone; microrna 27a ... See more keywords
LncRNA AK077216 promotes RANKL‐induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27031
Abstract: Osteoclasts derived from the monocyte/macrophage hematopoietic lineage regulate bone resorption, a process balanced by bone formation in the continual renewal of the skeletal system. As dysfunctions of these cells result in bone metabolic diseases such… read more here.
Keywords: bone resorption; bone; expression; lnc ak077216 ... See more keywords
A novel Bruton's tyrosine kinase inhibitor, acalabrutinib, suppresses osteoclast differentiation and Porphyromonas gingivalis lipopolysaccharide-induced alveolar bone resorption.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0334
Abstract: BACKGROUND Periodontitis is not only one of the most prevalent inflammatory diseases among adults, but also commonly linked to numerous systemic conditions including cardiovascular diseases, stroke, and diabetes. Although osteoclasts are responsible for the alveolar… read more here.
Keywords: osteoclast differentiation; bone resorption; induced alveolar; alveolar bone ... See more keywords
Risk indicators for marginal bone resorption around implants in function for at least 4 years: A retrospective longitudinal study.
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DOI: 10.1002/jper.18-0756
Abstract: BACKGROUND Marginal bone stability is considered one of the most important issues in implant dentistry. It is essential to understand how various factors influence bone resorption around implants. The purpose of this retrospective longitudinal study… read more here.
Keywords: marginal bone; bone resorption; resorption around; around implants ... See more keywords
6-Shogaol, an active ingredient of ginger, inhibits osteoclastogenesis and alveolar bone resorption in ligature-induced periodontitis in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.19-0228
Abstract: Periodontitis is an inflammatory disease of the tissues surrounding teeth that causes destruction of connective tissues. During the progress of periodontitis, osteoclasts are solely accountable for the resorption of alveolar bones that leads to the… read more here.
Keywords: resorption; bone resorption; ligature induced; periodontitis ... See more keywords