Higher fracture prevalence and smaller bone size in patients with hEDS/HSD—a prospective cohort study
Sign Up to like & getrecommendations! Published in 2019 at "Osteoporosis International"
DOI: 10.1007/s00198-019-05269-z
Abstract: Summary Increased fracture risk in patients with Ehlers-Danlos syndromes has been reported, but the reasons for it are incompletely understood. We aimed to investigate possible determinants of this increased risk and found that hEDS/HSD patients… read more here.
Keywords: bone size; fracture; muscle; bone ... See more keywords
Pleiotropic loci underlying bone mineral density and bone size identified by a bivariate genome-wide association analysis
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DOI: 10.1007/s00198-020-05389-x
Abstract: Aiming to identify pleiotropic genomic loci for bone mineral density and bone size, we performed a bivariate GWAS in five discovery samples and replicated in two large-scale samples. We identified 2 novel loci at 2q37.1… read more here.
Keywords: loci; bone size; genome wide; bone mineral ... See more keywords
Zebrafish endochondral growth zones as they relate to human bone size, shape and disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1060187
Abstract: Research on the genetic mechanisms underlying human skeletal development and disease have largely relied on studies in mice. However, recently the zebrafish has emerged as a popular model for skeletal research. Despite anatomical differences such… read more here.
Keywords: growth; disease; bone; growth zones ... See more keywords