Bone-targeted exosomes: Strategies and applications.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203361
Abstract: As the global population ages, bone-related diseases have increasingly become a major social problem threatening human health. Exosomes, as natural cell products, have been used to treat bone-related diseases due to their superior biocompatibility, biological… read more here.
Keywords: bone related; bone; bone targeted; related diseases ... See more keywords
Bone‐Targeted Fluoropeptide Nanoparticle Inhibits NF‐κB Signaling to Treat Osteosarcoma and Tumor‐Induced Bone Destruction
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202412014
Abstract: Osteosarcoma is a malignant bone cancer usually characterized by symptoms of bone loss due to pathologically enhanced osteoclast activity. Activated osteoclasts enhance bone resorption and promote osteosarcoma cell progression by secreting various cytokines. Intercepting the… read more here.
Keywords: bone targeted; targeted fluoropeptide; fluoropeptide nanoparticle; induced bone ... See more keywords
Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2021.04.038
Abstract: Antiresorptive drugs are widely used for treatment of osteoporosis and cancer bone metastasis, which function mainly through an overall inhibition of osteoclast. However, not all osteoclasts are “bone eaters”; preosteoclasts (pOCs) play anabolic roles in… read more here.
Keywords: bone targeted; responsive cerium; bone; targeted responsive ... See more keywords
Does Bone-targeted Therapy Benefit Patients with Metastatic Renal Cell Carcinoma?
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.10.009
Abstract: INTRODUCTION: In metastatic renal cell carcinoma (mRCC), the bone is the second most common site of metastasis and is associated with increased morbidity and poorer quality of life. Bone-targeted therapies (BTTs) such as denosumab and… read more here.
Keywords: renal cell; bone targeted; cell carcinoma; bone ... See more keywords
Bone-Targeted Supramolecular Nanoagonist Assembled by Accurate Ratiometric Herbal-Derived Therapeutics for Osteoporosis Reversal.
Sign Up to like & getrecommendations! Published in 2024 at "Nano letters"
DOI: 10.1021/acs.nanolett.4c00029
Abstract: Developing novel strategies for defeating osteoporosis has become a world-wide challenge with the aging of the population. In this work, novel supramolecular nanoagonists (NAs), constructed from alkaloids and phenolic acids, emerge as a carrier-free nanotherapy… read more here.
Keywords: bone targeted; supramolecular nanoagonist; herbal derived; osteoporosis ... See more keywords
Synthesis of new alendronate analogs for bone-targeted drug delivery strategies
Sign Up to like & getrecommendations! Published in 2024 at "New Journal of Chemistry"
DOI: 10.1039/d3nj04980a
Abstract: 1-Hydroxymethylene-1,1-bisphosphonate (HMBP) derivatives are widely used for the treatment of bone disorders and for bone imagery. Through their high affinity for bone matrix hydroxyapatite, they have shown promising development as... read more here.
Keywords: alendronate analogs; bone targeted; new alendronate; targeted drug ... See more keywords
Bone targeted new zoledronate derivative: design, synthesis, 99mTc-coupling, in-silico study and preclinical evaluation for promising osteosarcoma therapy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2022.2074162
Abstract: Abstract Background: Zoledronate suppresses human sarcomas by blocking the formation of geranylgeranyl diphosphate (GGPP) via inhibiting GGPP synthase. Objectives: Designing of new derivative of dronic acid (1-hydroxy-2-(4-nitro-1H-imidazol-1-yl)ethan-1,1-diyl)bis phosphonic acid), structurally related to zoledronate to be… read more here.
Keywords: osteosarcoma therapy; zoledronate; nitro zoledronate; bone targeted ... See more keywords
The role of bone-targeted therapies for prostate cancer in 2017
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Supportive and Palliative Care"
DOI: 10.1097/spc.0000000000000280
Abstract: Purpose of review Bone-targeted agents (BTAs), such as zoledronic acid and denosumab, delay the occurrence of skeletal-related events (SREs) in metastatic prostate cancer (PCa) patients. Recently, several agents, such as abiraterone acetate, enzalutamide and radium-223,… read more here.
Keywords: role bone; bone targeted; prostate cancer; bone ... See more keywords
Alendronate-Grafted Nanoemulsions for Bone-Targeted Vincristine Delivery: Preliminary Studies on Cell and Animal Models
Sign Up to like & getrecommendations! Published in 2024 at "Biomolecules"
DOI: 10.3390/biom14020238
Abstract: Bone is a site of distant metastases, which are a common cause of morbidity and mortality with a high socio-economic impact, for many malignant tumours. In order to engineer pharmacological therapies that are suitable for… read more here.
Keywords: bone targeted; delivery; nanoemulsions bone; grafted nanoemulsions ... See more keywords
Bone-Targeted Agents and Metastasis Prevention
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14153640
Abstract: Simple Summary Bone metastases are common in cancer patients and the role of bone-targeted agents in prevention of metastasis have been evaluated in multiple clinical trials over the past 20 years. Results show that in… read more here.
Keywords: bone; breast cancer; bone targeted; physiology ... See more keywords
Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics
Sign Up to like & getrecommendations! Published in 2020 at "Nanomaterials"
DOI: 10.3390/nano10050875
Abstract: Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to… read more here.
Keywords: bone targeted; delivery systems; drug; bone ... See more keywords