Bone-targeted exosomes: Strategies and applications.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203361
Abstract: As the global population ages, bone-related diseases have increasingly become a major social problem threatening human health. Exosomes, as natural cell products, have been used to treat bone-related diseases due to their superior biocompatibility, biological… read more here.
Keywords: bone related; bone; bone targeted; related diseases ... See more keywords
Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2021.04.038
Abstract: Antiresorptive drugs are widely used for treatment of osteoporosis and cancer bone metastasis, which function mainly through an overall inhibition of osteoclast. However, not all osteoclasts are “bone eaters”; preosteoclasts (pOCs) play anabolic roles in… read more here.
Keywords: bone targeted; responsive cerium; bone; targeted responsive ... See more keywords
Does Bone-targeted Therapy Benefit Patients with Metastatic Renal Cell Carcinoma?
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.10.009
Abstract: INTRODUCTION: In metastatic renal cell carcinoma (mRCC), the bone is the second most common site of metastasis and is associated with increased morbidity and poorer quality of life. Bone-targeted therapies (BTTs) such as denosumab and… read more here.
Keywords: renal cell; bone targeted; cell carcinoma; bone ... See more keywords
Bone targeted new zoledronate derivative: design, synthesis, 99mTc-coupling, in-silico study and preclinical evaluation for promising osteosarcoma therapy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2022.2074162
Abstract: Abstract Background: Zoledronate suppresses human sarcomas by blocking the formation of geranylgeranyl diphosphate (GGPP) via inhibiting GGPP synthase. Objectives: Designing of new derivative of dronic acid (1-hydroxy-2-(4-nitro-1H-imidazol-1-yl)ethan-1,1-diyl)bis phosphonic acid), structurally related to zoledronate to be… read more here.
Keywords: osteosarcoma therapy; zoledronate; nitro zoledronate; bone targeted ... See more keywords
The role of bone-targeted therapies for prostate cancer in 2017
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Supportive and Palliative Care"
DOI: 10.1097/spc.0000000000000280
Abstract: Purpose of review Bone-targeted agents (BTAs), such as zoledronic acid and denosumab, delay the occurrence of skeletal-related events (SREs) in metastatic prostate cancer (PCa) patients. Recently, several agents, such as abiraterone acetate, enzalutamide and radium-223,… read more here.
Keywords: role bone; bone targeted; prostate cancer; bone ... See more keywords
Bone-Targeted Agents and Metastasis Prevention
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DOI: 10.3390/cancers14153640
Abstract: Simple Summary Bone metastases are common in cancer patients and the role of bone-targeted agents in prevention of metastasis have been evaluated in multiple clinical trials over the past 20 years. Results show that in… read more here.
Keywords: bone; breast cancer; bone targeted; physiology ... See more keywords
Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics
Sign Up to like & getrecommendations! Published in 2020 at "Nanomaterials"
DOI: 10.3390/nano10050875
Abstract: Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to… read more here.
Keywords: bone targeted; delivery systems; drug; bone ... See more keywords
Treatment patterns and trends in patients dying of prostate cancer in Quebec: a population-based study.
Sign Up to like & getrecommendations! Published in 2017 at "Current oncology"
DOI: 10.3747/co.24.3598
Abstract: INTRODUCTION Since just after the year 2000 in Quebec, the management of metastatic castration-resistant prostate cancer (mcrpc) has evolved considerably, with the inclusion of docetaxel-based chemotherapy, bone-targeted therapies (zoledronic acid and denosumab), and more recently,… read more here.
Keywords: chemotherapy; bone targeted; targeted therapy; study ... See more keywords
EDTA-Modified 17β-Estradiol-Laden Upconversion Nanocomposite for Bone-Targeted Hormone Replacement Therapy for Osteoporosis
Sign Up to like & getrecommendations! Published in 2020 at "Theranostics"
DOI: 10.7150/thno.37599
Abstract: Hormone therapy (HT) is one of the most effective treatments for osteoporosis. However, the nonselective accumulation of hormone in organs such as breast, heart and uterus other than bones causes serious side effects, which impedes… read more here.
Keywords: hormone; bone targeted; edta; estradiol laden ... See more keywords
Induction of osteogenesis by bone-targeted Notch activation
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.60183
Abstract: Declining bone mass is associated with aging and osteoporosis, a disease characterized by progressive weakening of the skeleton and increased fracture incidence. Growth and lifelong homeostasis of bone rely on interactions between different cell types… read more here.
Keywords: activation; dll4 e12; induction osteogenesis; bone targeted ... See more keywords