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3
Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203361
Abstract: As the global population ages, bone-related diseases have increasingly become a major social problem threatening human health. Exosomes, as natural cell products, have been used to treat bone-related diseases due to their superior biocompatibility, biological…
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Keywords:
bone related;
bone;
bone targeted;
related diseases ... See more keywords
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Published in 2018 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4360
Abstract: To examine the dynamics of treatment with 2 bone‐targeting agents (BTAs)—denosumab and zoledronic acid—among men with bone metastases from prostate cancer.
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Keywords:
bone targeting;
bone metastases;
metastases prostate;
targeting agents ... See more keywords
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Published in 2018 at "Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s13139-017-0509-2
Abstract: Bone is a common metastatic site of cancer. Bone metastasis reduces life expectancy and results in serious symptoms and complications such as bone pain, pathological fractures, and spinal cord compression, decreasing quality of life by…
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Keywords:
bone targeting;
treatment bone;
targeting radiopharmaceuticals;
bone ... See more keywords
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Published in 2017 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-017-0407-2
Abstract: Synthetic parathyroid hormone (PTH) is clinically indicated for the treatment of osteoporosis, through its anabolic effects on parathyroid hormone receptors (PTHRs), located on osteoblast cells. However, the bioavailability of PTH for bone cells is restricted…
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Keywords:
pth;
bone targeting;
parathyroid hormone;
treatment osteoporosis ... See more keywords
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Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120819
Abstract: Extracellular adenosine has been shown to play a key role in maintaining bone health and could potentially be used to treat bone loss. However, systemic administration of exogenous adenosine to treat bone disorders remains a…
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Keywords:
bone targeting;
targeting nanocarrier;
bone;
bone loss ... See more keywords
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Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.11.028
Abstract: Abstract A dendritic bisphosphonate carrying three bisphosphonate (BP) units in close proximity was designed as a ligand to conjugate large therapeutic molecules for their bone selective delivery. The Bu3P-catalyzed conjugate addition of nitromethane to vinylidene…
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Keywords:
bone targeting;
dendritic bisphosphonates;
targeting ligands;
bisphosphonates bone ... See more keywords
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Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c04159
Abstract: Extracellular vesicles have received a great interest as safe biocarriers in biomedical engineering. There is a need to develop more efficient delivery strategies to improve localized therapeutic efficacy and minimize off-target adverse effects. Here, exosome…
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Keywords:
exosome mimetics;
bone tissue;
bone;
functionalization bone ... See more keywords
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Published in 2022 at "British dental journal"
DOI: 10.1038/s41415-022-3983-6
Abstract: This article discusses relevant information for the dental sector regarding metastatic cancers beyond breast and prostate cancer. Typically, tumour sites such as lung, renal, colorectal, gastrointestinal, thyroid, hepatic and pancreatic cancers are increasingly being referred…
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Keywords:
bone;
bone metastases;
presenting dental;
bone targeting ... See more keywords
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Published in 2019 at "RSC Advances"
DOI: 10.1039/c8ra09729a
Abstract: Fluorescent carbon dots selectively bind to skull tissues with high affinity, including a strong binding activity for calcium deficient hydroxyapatite, and rat femur, for bone targeted imaging.
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Keywords:
dots effect;
carbon dots;
affinity;
bone targeting ... See more keywords
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Published in 2019 at "Synthesis"
DOI: 10.1055/s-0037-1611540
Abstract: The synthesis of two bifunctional compounds bearing a terminal hydroxy-bisphosphonic function (HBP) was achieved following a linear and a convergent strategy. In the linear approach, the free hydroxy-bisphosphonic function was introduced in the last step…
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Keywords:
convergent syntheses;
hydroxy bisphosphonic;
syntheses bifunctional;
bone targeting ... See more keywords
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Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s188003
Abstract: Purpose PB is one of the most severe complications of late stage prostate cancer and negatively impacts patient quality of life. A major challenge for the treatment of cancer bone metastasis is the management of…
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Keywords:
vivo selex;
cancer bone;
prostate cancer;
bone targeting ... See more keywords