A Bone‐Targeting Hydrogen Sulfide Delivery System for Treatment of Osteoporotic Fracture via Macrophage Reprogramming and Osteoblast‐Osteoclast Coupling
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202418822
Abstract: The demand for systemic treatment of osteoporotic fractures to reduce recurrence is increasing, but current anti‐osteoporosis medications exhibit unsatisfactory efficacy due to adverse events and limited effects on fracture healing. Herein, a bone‐targeting zeolitic imidazolate… read more here.
Keywords: bone targeting; treatment osteoporotic; delivery; h2s ... See more keywords
Bone-targeted exosomes: Strategies and applications.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203361
Abstract: As the global population ages, bone-related diseases have increasingly become a major social problem threatening human health. Exosomes, as natural cell products, have been used to treat bone-related diseases due to their superior biocompatibility, biological… read more here.
Keywords: bone related; bone; bone targeted; related diseases ... See more keywords
Treatment dynamics of bone‐targeting agents among men with bone metastases from prostate cancer in the United States
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4360
Abstract: To examine the dynamics of treatment with 2 bone‐targeting agents (BTAs)—denosumab and zoledronic acid—among men with bone metastases from prostate cancer. read more here.
Keywords: bone targeting; bone metastases; metastases prostate; targeting agents ... See more keywords
Treatment of Bone Metastasis with Bone-Targeting Radiopharmaceuticals
Sign Up to like & getrecommendations! Published in 2018 at "Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s13139-017-0509-2
Abstract: Bone is a common metastatic site of cancer. Bone metastasis reduces life expectancy and results in serious symptoms and complications such as bone pain, pathological fractures, and spinal cord compression, decreasing quality of life by… read more here.
Keywords: bone targeting; treatment bone; targeting radiopharmaceuticals; bone ... See more keywords
Bone-targeting parathyroid hormone conjugates outperform unmodified PTH in the anabolic treatment of osteoporosis in rats
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-017-0407-2
Abstract: Synthetic parathyroid hormone (PTH) is clinically indicated for the treatment of osteoporosis, through its anabolic effects on parathyroid hormone receptors (PTHRs), located on osteoblast cells. However, the bioavailability of PTH for bone cells is restricted… read more here.
Keywords: pth; bone targeting; parathyroid hormone; treatment osteoporosis ... See more keywords
Bone targeting nanocarrier-assisted delivery of adenosine to combat osteoporotic bone loss.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120819
Abstract: Extracellular adenosine has been shown to play a key role in maintaining bone health and could potentially be used to treat bone loss. However, systemic administration of exogenous adenosine to treat bone disorders remains a… read more here.
Keywords: bone targeting; targeting nanocarrier; bone; bone loss ... See more keywords
Synthesis of dendritic bisphosphonates as bone targeting ligands
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.11.028
Abstract: Abstract A dendritic bisphosphonate carrying three bisphosphonate (BP) units in close proximity was designed as a ligand to conjugate large therapeutic molecules for their bone selective delivery. The Bu3P-catalyzed conjugate addition of nitromethane to vinylidene… read more here.
Keywords: bone targeting; dendritic bisphosphonates; targeting ligands; bisphosphonates bone ... See more keywords
Bone-Targeting Exosome Mimetics Engineered by Bioorthogonal Surface Functionalization for Bone Tissue Engineering.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c04159
Abstract: Extracellular vesicles have received a great interest as safe biocarriers in biomedical engineering. There is a need to develop more efficient delivery strategies to improve localized therapeutic efficacy and minimize off-target adverse effects. Here, exosome… read more here.
Keywords: exosome mimetics; bone tissue; bone; functionalization bone ... See more keywords
The presenting dental status of solid tumours with bone metastases requiring bone-targeting agents - part 4: miscellaneous cancers.
Sign Up to like & getrecommendations! Published in 2022 at "British dental journal"
DOI: 10.1038/s41415-022-3983-6
Abstract: This article discusses relevant information for the dental sector regarding metastatic cancers beyond breast and prostate cancer. Typically, tumour sites such as lung, renal, colorectal, gastrointestinal, thyroid, hepatic and pancreatic cancers are increasingly being referred… read more here.
Keywords: bone; bone metastases; presenting dental; bone targeting ... See more keywords
Bone-targeting carbon dots: effect of nitrogen-doping on binding affinity
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c8ra09729a
Abstract: Fluorescent carbon dots selectively bind to skull tissues with high affinity, including a strong binding activity for calcium deficient hydroxyapatite, and rat femur, for bone targeted imaging. read more here.
Keywords: dots effect; carbon dots; affinity; bone targeting ... See more keywords
Effects of chain lengths and backbone chirality on the bone-targeting ability of poly(glutamic acid)s.
Sign Up to like & getrecommendations! Published in 2024 at "Biomaterials science"
DOI: 10.1039/d4bm00437j
Abstract: Anionic synthetic polypeptides are promising candidates as standalone bone-targeting drug carriers. Nevertheless, the structure-property relationship of the bone-targeting ability of polypeptides remains largely unexplored. Herein we report the optimization of the in vitro and in… read more here.
Keywords: bone targeting; backbone chirality; targeting ability;