Prostatic injection of botulinum toxin is not inferior to optimized medical therapy in the management of lower urinary tract symptoms due to benign prostatic hyperplasia: results of a randomized clinical trial
Sign Up to like & getrecommendations! Published in 2018 at "World Journal of Urology"
DOI: 10.1007/s00345-018-2193-y
Abstract: ObjectiveTo explore efficacy and safety of Botulinum Neurotoxin Type A (BoNT-A) prostatic injection in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperperplasia.Materials and methodsA phase 3 multicenter open-labeled study randomised patients… read more here.
Keywords: prostatic injection; medical therapy; bont; therapy ... See more keywords
The effect of botulinum toxin on ureteral inflammation
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Urology"
DOI: 10.1007/s00345-020-03365-y
Abstract: Purpose The impact of onabotulinum toxin type A (BoNT-A) on bladder afferent nerve pathways and chemosensory functions is an active area of investigation. There may be a role for BoNT-A in disorders of the ureter;… read more here.
Keywords: inflammation; effect; bont; toxin ... See more keywords
Impact of COVID-19 on neurological patients attending a botulinum toxin service
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04940-2
Abstract: Sir, On January 30, 2020, the World Health Organization (WHO) declared the emergence of a novel coronavirus (here named COVID-19), firstly reported few weeks earlier in Wuhan, Hubei Province of China, as a public health… read more here.
Keywords: patients attending; treatment; bont; service ... See more keywords
Immunogenicity of Botulinum Toxin Formulations: Potential Therapeutic Implications
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DOI: 10.1007/s12325-021-01882-9
Abstract: Botulinum neurotoxins (BoNTs) are proteins produced by bacteria of the Clostridium family. Upon oral ingestion, BoNT causes the neuroparalytic syndrome botulism. There are seven serotypes of BoNT (serotypes A-G); BoNT-A and BoNT-B are the botulinum… read more here.
Keywords: immunogenicity; treatment; bont; botulinum ... See more keywords
OnabotulinumtoxinA in Chronic Migraine: A Profile of Its Use
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DOI: 10.1007/s40263-020-00776-8
Abstract: OnabotulinumtoxinA (Botox®; a formulation of botulinum toxin type A (BoNT/A)] is indicated for the prevention of headaches in adults with chronic migraine (CM) in numerous countries, including those of Europe. In clinical trials, intramuscular administration… read more here.
Keywords: migraine; profile use; bont; onabotulinumtoxina chronic ... See more keywords
Botulinum toxin A alleviates orofacial nociception induced by orthodontic tooth movement through nociceptin/orphanin-FQ pathway in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2020.104817
Abstract: OBJECTIVES To investigate the effect and mechanism of botulinum neurotoxin type A (BoNT/A) in the modulation of orofacial nociception induced by orthodontic tooth movement in rats. METHODS An orofacial nociception model was established in male… read more here.
Keywords: orofacial nociception; group; bont; force ... See more keywords
Botulinum Neurotoxin and Its Potential Role in the Treatment of Erectile Dysfunction.
Sign Up to like & getrecommendations! Published in 2018 at "Sexual medicine reviews"
DOI: 10.1016/j.sxmr.2017.07.008
Abstract: INTRODUCTION Botulinum toxin type A (BoNT-A) has been used to treat several striated and smooth muscle disorders. During the past year, human and animal studies conducted in Egypt and Canada by two different groups of… read more here.
Keywords: medicine; treatment; erectile dysfunction; bont ... See more keywords
Pore Size-Dependent Stereoscopic Hydrogels Enhance the Therapeutic Efficiency of Botulinum Toxin for the Treatment of Nerve-Related Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c01738
Abstract: Botulinum toxin (BoNT) is a major neurotherapeutic protein that has been used at low doses for diverse pharmacological applications. However, the pleiotropic effect of BoNT depends on multiple periodic injections owing to its rapid elimination… read more here.
Keywords: bont; treatment; botulinum toxin; single dose ... See more keywords
Injection of high dose botulinum-toxin A leads to impaired skeletal muscle function and damage of the fibrilar and non-fibrilar structures
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DOI: 10.1038/s41598-017-14997-3
Abstract: Botulinum-toxin A (BoNT/A) is used for a wide range of conditions. Intramuscular administration of BoNT/A inhibits the release of acetylcholine at the neuromuscular junction from presynaptic motor neurons causing muscle-paralysis. The aim of the present… read more here.
Keywords: muscle; high dose; tissue; bont ... See more keywords
Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid
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DOI: 10.1038/s41598-022-05008-1
Abstract: Botulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a multipurpose therapeutic. Nevertheless, as the most… read more here.
Keywords: clostridium botulinum; construction validation; strain; botulinum ... See more keywords
Long-term efficacy and safety of botulinum toxin treatment for cervical dystonia: a critical reappraisal
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2021.1915282
Abstract: ABSTRACT Introduction: Botulinum toxin (BoNT) injections represent the gold standard treatment for cervical dystonia (CD). Different types of BoNT have been used for the treatment of CD, but only two serotypes, BoNT type A (BoNT-A)… read more here.
Keywords: term; efficacy safety; long term; treatment ... See more keywords