Boosting Endogenous Copper(I) for Biologically Safe and Efficient Bioorthogonal Catalysis via Self-Adaptive Metal-Organic Frameworks.
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DOI: 10.1021/jacs.2c12374
Abstract: As one of the most typical bioorthogonal reactions, the Cu(I)-catalyzed azide-alkyne 1,3-cycloaddition (CuAAC) reaction has received worldwide attention in intracellular transformation of prodrugs due to its high efficiency and selectivity. However, the exogenous Cu catalysts… read more here.
Keywords: catalysis; boosting endogenous; bioorthogonal catalysis; metal organic ... See more keywords