Boosting ER-mitochondria calcium transfer to treat Wolfram syndrome.
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DOI: 10.1016/j.ceca.2022.102572
Abstract: Wolfram syndrome is a rare genetic disorder characterized by endocrine dysfunction and progressive neurodegeneration. By targeting intracellular calcium dysregulations, a sigma-1 receptor agonist rescued neurological deficits in preclinical models of Wolfram syndrome. read more here.
Keywords: boosting mitochondria; wolfram syndrome; calcium; calcium transfer ... See more keywords